Figure 8.

Membrane and firing properties of SOM-INs from Som-TSC1-KO mice. A, Representative electrophysiological responses (top) of SOM-INs to current pulse injections (bottom) from Som-TSC1-WT (left) and Som-TSC1-KO (right) mice. Depolarizing current pulses correspond to near threshold (red) and 3× threshold (blue) stimulation. B, Membrane and firing properties of SOM-INs from Som-TSC1-WT and Som-TSC1-KO mice, showing intact resting membrane potential, specific membrane capacitance, latency to first action potential (AP), rheobase, AP threshold, AP amplitude, AP half-width, firing rate at rheobase ×2 and adaptation ratio at rheobase ×3; and reduced input resistance and fAHP amplitude. *p < 0.05; ns, not significant.