Figure 9.

Tsc1 deletion in SOM-INs increased long-term contextual fear memory but impaired context discrimination. A, Representative paths traveled by Som-TSC1-WT (left) and Som-TSC1-KO (right) mice during 5 min free exploration in a square open-field. B, Anxiety properties of Som-TSC1-WT and Som-TSC1-KO mice: percentage of time freezing in the center and in the periphery, and center/periphery ratio. C, Locomotion properties of Som-TSC1-KO mice: total distance traveled, number of zone transitions, resting time and running speed. D, Diagram of the contextual fear conditioning protocol. E, Percentage of time freezing after each foot shock during the training session for Som-TSC1-WT and Som-TSC1-KO mice (0: before the first foot shock). F, Percentage of time freezing during the probe tests at 1 h and at 24 h after conditioning. G, Percentage of time freezing (left) and discrimination ratio (right) during the contextual discrimination test. H, Diagram of the auditory-cued fear conditioning protocol. I, Percentage of time freezing during the training session (left) and during the probe test 24 h after (right) for Som-TSC1-WT and Som-TSC1-KO mice. **p < 0.01; ***p < 0.001; ns, not significant.