Fig. 2.

(A) Schematic representation of the experimental setup to induce atherosclerotic lesion formation in the aorta of ApoE−/− mice and the time periods of SAHA/vehicle administration to mice. (B–F) Assessment of body weight and plasma levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides for each animal group at the end of the treatment procedure. n = 8–12, ***P < 0.001. P-values were taken in relation to ApoE−/− (ND) condition.