Fig. 6.

Activation of HDAC-dependent signalling pathways augments the protein expression levels of Nox subtypes in the atherosclerotic aorta of ApoE−/− mice. (A–C) Quantification of Western blot data showing the fold changes in Nox1, Nox2, and Nox4 protein expression levels in the aorta of vehicle- or SAHA-treated ApoE−/− mice maintained on normal (ND) or high-fat, cholesterol-rich diet (HD). (D–F) Representative immunoblots depicting the regulation of Nox1, Nox2, and Nox4 expression in the aortic protein extracts derived from each animal group. n = 4–5, *P < 0.05. P-values were taken in relation to ApoE−/− (HD) condition.