Figure 4.

MAGI2-AS3 Reduces H3K4me2 Methylation of the RACGAP1 Promoter via Recruiting KDM1A

(A) The expression of KDM1A in HCCLM3 cells infected with lentivirus harboring KDM1A sequence as detected by qRT-PCR. (B) MAGI2-AS3 expression in HCCLM3 cells infected with sh-MAGI2-AS3 as detected by qRT-PCR. (C) The enrichment of H3K4me2 in the RACGAP1 promoter region of HepG2 cells after MAGI2-AS3 overexpression or knockdown as detected by ChIP. (D) The enrichment of H3K4me2 in the RACGAP1 promoter region after KDM1A overexpression or knockdown as detected by ChIP. *p < 0.05 versus oe-NC group; ^#p < 0.05 versus sh-NC group; p < 0.05 versus IgG group. The experiments were repeated three times independently, and the data were analyzed using unpaired t test or one-way ANOVA.