Table 1.
Summary of Characteristics of Animals Used in the Study
| Animal ID | Species | Gender | Age (Years) | Injection #1 |
Injection #2 |
Readmin. Bleb Locationsa |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Right Eye |
Left Eye |
Right Eye |
Left Eye |
|||||||||
| Volume (μL) | Dose [vg × 1011] | Volume (μL) | Dose (vg × 1011) | Volume (μL) | Dose (vg × 1011) | Volume (μL) | Dose (vg × 1011) | |||||
| 10C015 | cynomolgus (Macaca fascicularis) | F | 8 | 180 | 1.8 | 120 | 1.2 | 200 | 2.0 | 150 | 1.5 | no overlap |
| BF54F | rhesus (Macaca mulatta) | M | 9 | 100 | 1.0 | 150 | 1.5 | 150 | 1.5 | 150 | 1.5 | partial overlap |
| 11D086 | cynomolgus (Macaca fascicularis) | F | 7 | 180 | 1.8 | 120 | 1.2 | 200 | 2.0 | 200 | 2.0 | complete overlap |
Age is given for the first injection time point. vg, vector genomes.
a
Relative position of the readministered (readmin.) subretinal bleb in relationship to initial bleb that resulted from the first injection.