Table 1.

Relationships between AAV Serotype Receptor Usage and Tropism are supported by references13, 14, 18, 20, 59, 60, 61

Glycan Receptor Serotype Usage	AAV Serotype	Impact on Tropism
Heparan sulfate proteoglycan	AAV2, AAV3, AAV6, and AAV13	AAV2 muscle cell interactions
α2–3 and α2–6 N-linked sialic acid (SIA)	AAV1, AAV4, AAV5, and AAV6	AAV5 airway epithelial cell interactions
Laminin receptor	AAV8	widely expressed on tissues targeted by AAV8 including heart, liver, and skeletal muscle
Terminal N-linked galactose of SIA	AAV9	may enable the ability of AAV9 to cross the blood-brain barrier and transduce neural tissues
AAV receptor (AAVR, KIAA0319L)	AAV1, AAV2, AAV3B, AAV5, AAV6, AAV8, and AAV9	AAVR is critical for the entry of numerous AAV serotypes