Table 2.
Variable tested | CRP (mg/l) | CEA (ng/ml) | SCC‐Ag (ng/ml) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Median | Range | P‐value | Median | Range | P‐value | Median | Range | P | ||
Group tested | ESCC (n = 30) | 14.7A | 5.0–149.5 | <0.001* | 2.4A | 0.4–8.5 | <0.001* | 1.5A | 0.6–34.5 | <0.001* |
Control group (n = 90) | 5.0 | 0.1–13.9 | 0.8 | 0.1–11.4 | 1.0 | 0.6–4.0 | ||||
TNM stage | I + IIa + IIb (n = 10) | 5.6** A | 5.0–64.9 | 0.014* | 1.7** A | 0.4–3.3 | 0.011* | 1.3** , *** | 0.8–4.3 | 0.006* |
III (n = 14) | 20.5A | 5.0–134.8 | 2.9A | 1.5–8.5 | 1.5** A | 0.6–8.2 | ||||
IV (n = 6) | 42.2A | 21.2–149.5 | 4.2A | 1.7–7.3 | 15.3A | 1.5–34.5 | ||||
Depth of tumor invasion (T factor) | T1 + T2 (n = 6) | 5.6A | 5.0–37.2 | 0.226 | 1.6 | 0.4–5.0 | 0.214 | 1.4 | 0.9–24.4 | 0.726 |
T3 (n = 12) | 30.7A | 5.0–79.9 | 2.4A | 0.9–7.2 | 1.4A | 0.8–34.5 | ||||
T4 (n = 12) | 17.1A | 5.0–149.5 | 2.9A | 1.5–8.5 | 1.6A | 0.6–19.6 | ||||
Nodal involvement (N factor) | N0 (n = 10) | 5.0A | 5.0–64.9 | 0.006* | 1.9A | 0.4–3.3 | 0.009* | 1.2 | 0.8–4.3 | 0.050* |
N1 (n = 20) | 29.0A | 5.0–149.5 | 3.1A | 1.4–8.5 | 1.7A | 0.6–34.5 | ||||
Distant metastases (M factor) | M0 (n = 24) | 7.7A | 5.0–134.8 | 0.014* | 2.3A | 0.4–8.5 | 0.087 | 1.5A | 0.6–8.2 | 0.001* |
M1 (n = 6) | 42.2A | 21.2–149.5 | 4.2A | 1.7–7.3 | 15.3A | 1.5–34.5 | ||||
Differentiation of tumor | G1 (n = 6) | 8.4A | 5.0–79.9 | 0.858 | 2.1A | 0.5–3.1 | 0.418 | 1.2 | 0.9–2.5 | 0.234 |
G2 (n = 13) | 13.0A | 5.0–149.5 | 2.5A | 0.9–8.5 | 1.9A | 1.0–19.6 | ||||
G3 (n = 9) | 21.2A | 5.0–75.5 | 2.5A | 0.4–7.3 | 1.5A | 0.6–34.5 | ||||
Survival of patients | Alive (n = 12) | 5.4A | 5.0–79.9 | 0.040* | 2.4A | 0.4–8.5 | 0.595 | 1.3A | 0.8–4.3 | 0.075 |
Died of cancer (n = 18) | 24.1A | 5.0–149.5 | 2.4A | 1.4–7.3 | 1.8A | 0.6–34.5 |
*Statistically significant when P < 0.05.
**Statistically significant in comparison with stage IV post hoc Dwass‐Steel‐Critchlow‐Fligner test.
***Statistically significant in comparison with stage III post hoc Dwass‐Steel‐Critchlow‐Fligner test.
Statistically significant in comparison with control group.