Table 3.

The Concentrations of C‐Reactive Protein (CRP) and Classic Tumor Markers (Carcinoembryonic Antigen—CEA and Squamous Cell Cancer Antigen—SCC‐Ag) in the Sera of Patients with Adenocarcinoma of Esophagus (AC)

Variable tested		CRP (mg/l)			CEA (ng/ml)			SCC‐Ag (ng/ml)
		Median	Range	P‐value	Median	Range	P	Median	Range	P‐value
Group tested	AC (n = 23)	6.2A	5.0–45.5	<0.001*	2.5A	0.4–40.4	<0.001*	0.9	0.4–4.5	0.301
	Control group (n = 90)	5.0	0.1–13.9		0.8	0.1–11.4		1.0	0.6–4.0
TNM stage	I + IIa + IIb (n = 3)	5.0	5.0–45.5	0.995	1.9	0.5–2.6	0.257	1.0	0.9–1.4	0.600
	III (n = 16)	7.8A	5.0–41.8		4.0A	0.4–40.4		0.9	0.4–4.5
	IV (n = 4)	10.3	5.0–40.5		1.2	0.4–7.8		0.9	0.5–1.0
Depth of tumor invasion (T factor)	T1 + T2 (n = 3)	5.0	5.0–45.5	0.357	1.9	0.5–2.6	0.676	1.0	0.9–1.4	0.038*
	T3 (n = 15)	5.0A	5.0–45.5		2.5A	0.8–40.4		0.9	0.4–4.5
	T4 (n = 15)	20.9	5.0–41.8		7.5	0.4–23.8		0.7**	0.5–0.9
Nodal involvement (N factor)	N0 (n = 3)	5.0	5.0–45.5	0.923	1.9	0.5–2.6	0.411	1.0	0.9–1.4	0.463
	N1 (n = 20)	7.8A	5.0–41.8		2.6A	0.4–40.4		0.9	0.4–4.5
Distant metastases (M factor)	M0 (n = 19)	6.2A	5.0–45.5	0.966	2.6A	0.4–40.4	0.208	0.9	0.4–4.5	0.415
	M1 (n = 4)	10.3	5.0–40.5		1.2	0.4–7.8		0.9	0.5–1.0
Differentiation of tumor	G1 (n = 4)	7.2	5.0–15.5	0.222	2.2A	0.9–7.8	0.781	1.2	1.0–4.5	0.090
	G2 (n = 12)	5.0A	5.0–45.5		2.7A	0.5–40.4		0.9	0.4–2.2
	G3 (n = 7)	23.0A	5.0–41.8		1.6	0.4–23.8		0.7A	0.5–1.4
Survival of patients	Alive (n = 15)	5.0A	5.0–41.8	0.259	2.6A	0.4–40.4	0.301	1.0	0.4–2.2	0.364
	Died of cancer (n = 8)	18.2A	5.0–45.5		1.2	0.4–23.8		0.9	0.5–4.5

^*Statistically significant when P < 0.05.

^**Statistically significant in comparison with stage III post hoc Dwass‐Steel‐Critchlow‐Fligner test, P = 0.047.

^aStatistically significant in comparison with control group.