Fig. 9.

Linear predictions and associated confidence bands are superimposed on 183 FBA samples (61 subjects at each of three follow-up sessions) for (A) ‖$\text{roi}\_\Delta {\text{FA}}_{\text{WM}}^{+}$‖; (B) ‖$\text{roi}\_\Delta {\text{MD}}_{\text{WM}}^{+}$‖; (C) ‖$\text{roi}\_\Delta {\text{FA}}_{\text{WM}}^{-}$‖; (D) ‖$\text{roi}\_\Delta {\text{MD}}_{\text{WM}}^{-}$‖. A significant linear regression (Bonferroni-corrected; see Table 4) was found in FBA for the spatial extent of the ROI_WM signed change mask associated with a decrease in FA ($\text{roi}\_\Delta {\text{FA}}_{\text{WM}}^{-}$), as a function of the cumulative count of HAEs exceeding 20 g. This white matter change (decreased FA) is typically associated with neural injury (e.g., Wieshmann et al., 1999, Arfanakis et al., 2002, Kraus et al., 2007, Mac Donald et al., 2007a, Mac Donald et al., 2007b; Mac Donald et al., 2007a, Mac Donald et al., 2007b; Shitaka et al., 2011, Magnoni et al., 2015, Sundman et al., 2015, Pan et al., 2016, Kantarci et al., 2017). The symbol r represents a Pearson's correlation coefficient.