Fig. 13.

Linear predictions and associated confidence bands are superimposed on 183 FBA samples (61 subjects at each of three follow-up sessions) for (A) ‖$\text{roi}\_\Delta {\text{FA}}_{\text{ALT}}^{+}$‖; (B) ‖$\text{roi}\_\Delta {\text{MD}}_{\text{ALT}}^{+}$‖; (C) ‖$\text{roi}\_\Delta {\text{FA}}_{\text{ALT}}^{-}$‖; (D) ‖$\text{roi}\_\Delta {\text{MD}}_{\text{ALT}}^{-}$‖. Significant linear regressions (Bonferroni-corrected; see Table 8) were found in FBA for the spatial extent of the ROI_ALT signed change masks associated with (i) a decrease in FA ($\text{roi}\_\Delta {\text{FA}}_{\text{ALT}}^{-}$), and (ii) an increase in MD ($\text{roi}\_\Delta {\text{MD}}_{\text{ALT}}^{+}$), as a function of the cumulative count of HAEs exceeding 20 g. The white matter changes with which statistically-significant regressions were observed—increased MD and decreased FA—are typically associated with neural injury (e.g. Wieshmann et al., 1999, Arfanakis et al., 2002, Kraus et al., 2007, Mac Donald et al., 2007a, Mac Donald et al., 2007b; Shitaka et al., 2011, Magnoni et al., 2015, Sundman et al., 2015, Pan et al., 2016, Kantarci et al., 2017). The symbol r represents a Pearson's correlation coefficient.