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. 2019 Oct 8;30:140–151. doi: 10.1016/j.molmet.2019.09.012

Figure 2.

Figure 2

SCN-BKO mice retain molecular clock gene rhythms in peripheral tissues under light-dark, but not under constant darkness conditions. A) mRNA expression profiles of Bmal1, Per2, Dbp and RevErbα (Nr1d1) at four time points (Zeitgeber time (ZT) 1 = 1 h after “lights on”) under light-dark conditions in control (black) and SCN-BKO animals (red) in pancreas, liver, and epididymal white adipose tissue. B) mRNA expression of Bmal, Per2, Dbp, and RevErbα at four time points (circadian time (CT) 1 = 37 h after “lights off”) under constant darkness conditions in control and SCN-BKO animals in pancreas, liver and epididymal white adipose tissue (n = 3–5 animals per time point and genotype, #: rhythmic gene expression, p < 0.05, CircWave analysis).