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. 2019 Oct 8;30:140–151. doi: 10.1016/j.molmet.2019.09.012

Figure 4.

Figure 4

SCN-BKO mice gain fat mass under constant darkness, but not under light-dark conditions. A) Body weight gain (left) and cumulative food intake (right) of control (black) and SCN-BKO (red) mice in light-dark over 10 weeks (weight ANOVA: interaction: p > 0.999; time: p < 0.001; genotype: p = 0.478; food ANOVA: interaction: p = 0.993; time: p < 0.001; genotype: p = 0.064). B) Body weight gain (left) and cumulative food consumption (right) of control (black) and SCN-BKO (red) mice in constant darkness over 10 weeks (n = 6 animals per genotype, *: p < 0.05, 2-way ANOVA with Bonferroni post-test) (weight ANOVA: interaction: p < 0.001; time: p < 0.001; genotype: p = 0.055; food ANOVA: interaction: p > 0.999; time: p < 0.001; genotype: p = 0.002). C) Body fat distribution analysis. Raw MRI image (left) and marking of visceral (red) and subcutaneous (yellow) adipose tissue (right). White bar corresponds to 100 mm. Evaluation of body fat depot volume of subcutaneous (Sub) and visceral (Vis) adipose tissue in control (black) and SCN-BKO (red) mice after 10 weeks in constant darkness with chow ad libitum (n = 6 animals per genotype, *: p < 0.05, 2-way ANOVA; interaction: p = 0.214; depot: p = 0.002; genotype: p = 0.003).