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. 2019 Oct 8;30:140–151. doi: 10.1016/j.molmet.2019.09.012

Figure 7.

Figure 7

Restricted feeding reduces food intake in SCN-BKO animals and normalizes glucose response, body weight, and body composition. A) Body weight gain (left) and cumulative food intake (right) of control (black) and SCN-BKO (red) mice in restricted feeding conditions over 10 weeks (weight ANOVA: interaction: p = 0.492; time: p < 0.001; genotype: p = 0.697; food ANOVA: interaction: p < 0.001; time: p < 0.001; genotype: p = 0.004). B) Intraperitoneal glucose (ANOVA: interaction: p = 0.801; time: p < 0.001; genotype: p = 0.671) and C) insulin tolerance tests (ANOVA: interaction: p = 0.884; time: p < 0.001; genotype: p = 0.928) under restricted feeding conditions in control (black) and SCN-BKO (red) animals with the corresponding incremental area under the curve (iAUC) evaluations on the right (n = 6 animals per genotype, iAUC: Student's t-test) D) Body fat depot volume (left) of subcutaneous and visceral adipose tissue in control (grey) and SCN-BKO (red) mice after 10 weeks in restricted feeding (ANOVA: interaction: p = 0.597; depot: p < 0.009; genotype: p = 0.132). Body weight gain per week of control and SCN-BKO animals in light-dark and constant darkness ad libitum and restricted feeding conditions (right; n = 6 animals per genotype, *: p < 0.05, 2-way ANOVA with Bonferroni post-test).