Table 3.
Gene Mutations Associated With Drug‐Resistant M. tuberculosis Strains
| Subfamilya (number of isolates) | INHb resistance | Gene mutations | RIFb resistance | Gene mutations |
|---|---|---|---|---|
| Family34 (4) | 1 (8.33%)c | katG (1/1) | 1 (14.28%)d | None detected |
| Family36 (1) | 1 (8.33%)c | katG (1/1) | 0 | – |
| H37Rv (6) | 1 (8.33%)c | katG (1/1) | 0 | – |
| LAM9 (14) | 4 (33.33%)c | katG (4/4) | 3 (42.85%)d | rpoB516 y 526(1/3) |
| T1 (13) | 2 (16.66%)c | katG (1/2) | 2 (28.57%)d | rpoB526(1/2) |
| T2 (1) | 1 (8.33%)c | katG (1/1) | 0 | |
| X1 (6) | 2 (16.66%)c | katG (1/2) | 1 (14.28%)d | rpoB526(1/1) |
a
SPOTCLUST assigned lineage to M. tuberculosis strains.
b
Isoniazid‐ or rifampicin‐resistant isolates/total of isolates in the M. tuberculosis subfamily.
c
INH relative resistance = number of resistant strains in subfamilies/total of resistant strains (12).
d
RIF relative resistance = number of resistant strains in subfamilies/total of resistant strains (7).