Table 2.
Genotype and Allele Frequencies of TDP1 Polymorphism rs28365054 (c.400G>A, Ala134Thr) in TS Patients and Controls
| Test | Genotype/allele | Cases number (%) | HWEa | Controls number (%) | HWE | P value | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| Genotypic association | GG | 32 (26.23) | 0.01 b | 36 (33.96) | 0.30b | 0.0402 b | 1.28 (0.70–2.33) |
| GA | 74 (60.66) | 47 (44.34) | 2.26 (1.08–4.72) | ||||
| AA | 16 (13.11) | 23 (21.70) | 1 | ||||
| Additive model | GG | 32 (26.23) | 36 (33.96) | 0.9535c | |||
| GA | 74 (60.66) | 47 (44.34) | |||||
| AA | 16 (13.11) | 23 (21.70) | |||||
| Dominant model | AA+GA | 90 (73.77) | 70 (66.04) | 0.2031b | |||
| GG | 32 (26.23) | 36 (33.96) | |||||
| Recessive model | AA | 16 (13.11) | 23 (21.70) | 0.0860b | |||
| GG+GA | 106 (86.89) | 83 (78.30) | |||||
| Allelic association | G | 138 (56.56) | 119 (56.36) | n/ad | 1.02 (0.70–1.47) | ||
| A | 106 (43.44) | 93 (43.64) | 1 |
a
HWE: P values of the Hardy–Weinberg equilibrium test.
b
P values were calculated using the χ2 test. P values less than 0.05 are highlighted in bold.
c
P value was calculated using the Cochran–Armitage test.
d
Violate the assumption of the allelic association test (multiplicative model) due to departures from
Hardy–Weinberg equilibrium.
OR: odds ratio; 95% CI: 95% confidence interval.