Table 2.

Comparisons of the Parameters Related to Oxidative Stress and the Antioxidant Status between the Patients and the Controlsa

	Hb H disease (n = 26)	Controls (n = 75)
Variables	Median value (IQR)b	Median value (IQR)
${\mathrm{O}}_2^{.-}$ (−PMA), counts/ 10 sec × 103 WBC	592 (316)*	208 (169)
${\mathrm{O}}_2^{.-}$ (+PMA), counts/ 10 sec × 103 WBC	6,302 (3,789)*	2,858 (2,163)
Nitrite, μmol/l	22.0 (20.1)*	13.3 (9.1)
Nitrate, μmol/l	55.9 (25.1)*	68.8 (27.3)
Total NO, μmol/l	81.8 (31.0)	80.5 (30.2)
GSH, μmol/l	1,153 (401)*	1,338 (344)
GSSG, μmol/l	93.6 (56.0)*	113.0 (50.6)
SOD, U/g Hb	1,067 (260)*	574 (95)
GPx, U/g Hb	163 (50.9)*	50.5 (10.4)
GRx, U/g Hb	13.2 (5.6)*	10.6 (3.0)
MDA, μmol/l	4.2 (1.5)*	1.4 (0.2)
Vitamin C, μmol/l	25.6 (35.0)*	43.6 (38.9)

^aThe independent sample data used for the Mann–Whitney U test are expressed as a median value (IQR).

^b*P < 0.05 when compared with those of the controls.

${\mathrm{O}}_2^{.-}$, superoxide anion; PMA, phorbol 12‐myristate 13‐acetate; MDA, malondialdehyde, GSH, reduced glutathione; GSSG, oxidized glutathione; SOD, superoxide dismutase; GPx, glutathione peroxidase; GRx, glutathione reductase.