Table 3.
Comparison of Background Characteristics Among the Different Genotypes of the MTHFR 677C/T Polymorphism in the Study Groups
| MTHFR 677 C/T genotypes | ||||||
|---|---|---|---|---|---|---|
| Groups | CC | TT + CT | P‐value | TT | CC + CT | P‐value |
| DM (‐) CHD patients | ||||||
| TC (mmol/L) | 5.54 ± 1.59 | 5.64 ± 1.09 | 0.714 | 5.54 ± 1.28 | 5.59 ± 1.41 | 0.980 |
| TG (mmol/L) | 1.59 ± 0.82 | 1.68 ± 0.64 | 0.528 | 1.57 ± 0.71 | 1.63 ± 0.75 | 0.575 |
| HDL‐C (mmol/L) | 1.03 ± 0.17 | 1.03 ± 0.21 | 0.833 | 0.96 ± 0.28 | 1.04 ± 0.17 | 0.828 |
| LDL‐C (mmol/L) | 3.46 ± 1.22 | 3.71 ± 0.94 | 0.237 | 3.74 ± 1.02 | 3.56 ± 1.12 | 0.793 |
| VLDL‐C (mmol/L) | 0.72 ± 0.36 | 0.74 ± 0.30 | 0.827 | 0.71 ± 0.33 | 0.73 ± 0.34 | 0.411 |
| BMI (kg/m2) | 26.20 ± 3.57 | 26.78 ± 2.60 | 0.330 | 26.45 ± 2.16 | 26.45 ± 3.27 | 0.166 |
| ≥27 kg/m2 | 29 53.70%) | 25 (46.30%) | 0.539 | 5 (9.30%) | 49 (90.70%) | 0.772 |
| <27 kg/m2 | 31 (59.60%) | 21 (40.40%) | 4 (7.70%) | 48 (92.30%) | ||
| SBP (mmHg) | 131.34 ± 35.53 | 125.43 ± 22.48 | 0.322 | 126.25 ± 30.67 | 128.77 ± 30.23 | 0.871 |
| DBP (mmHg) | 81.53 ± 16.52 | 77.60 ± 14.44 | 0.216 | 77.50 ± 14.88 | 79.88 ± 15.75 | 0.726 |
| DM (+) CHD patients | ||||||
| TC (mmol/L) | 5.19 ± 1.40 | 4.87 ± 1.31 | 0.301 | 5.25 ± 1.21 | 4.99 ± 1.39 | 0.539 |
| TG (mmol/L) | 1.92 ± 0.88 | 1.67 ± 1.27 | 0.314 | 2.08 ± 2.02 | 1.74 ± 0.79 | 0.569 |
| HDL‐C (mmol/L) | 0.96 ± 0.25 | 1.00 ± 0.25 | 0.492 | 1.03 ± 0.18 | 0.97 ± 0.26 | 0.462 |
| LDL‐C (mmol/L) | 3.25 ± 1.08 | 2.90 ± 0.99 | 0.151 | 3.02 ± 1.18 | 3.09 ± 1.02 | 0.807 |
| VLDL‐C (mmol/L) | 0.86 ± 0.35 | 0.80 ± 0.70 | 0.614 | 1.05 ± 1.13 | 0.78 ± 0.32 | 0.411 |
| BMI (kg/m2) | 27.84 ± 4.24 | 24.53 ± 3.31 | 0.002 | 24.09 ± 3.38 | 26.59 ± 4.16 | 0.094 |
| ≥ 27 kg/m2 | 19 (73.10%) | 7 (26.90%) | 0.002 | 3 (11.50%) | 23 (88.50%) | 0.481 |
| < 27 kg/m2 | 11 (33.30%) | 22 (66.70%) | 6 (18.20%) | 27 (81.80%) | ||
| SBP (mmHg) | 138.55 ± 25.99 | 127.05 ± 28.01 | 0.075 | 131.81 ± 23.58 | 133.36 ± 28.19 | 0.865 |
| DBP (mmHg) | 84.47 ± 16.18 | 78.08 ± 17.40 | 0.111 | 80.45 ± 11.92 | 81.63 ± 17.78 | 0.833 |
DM(+)CHD, patients with diabetes; DM(−) CHD, coronary heart disease (CHD) patients without diabetes; TC, total cholesterol; TG, triglyceride; LDL‐C, low‐density lipoprotein‐cholesterol; HDL‐C, high‐density lipoprotein‐cholesterol; VLDL‐C, very low‐density lipoprotein‐cholesterol; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure. The results are shown as mean ± SD. Bold values of P indicate statistical significance.