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. 2019 Oct 16;10:986. doi: 10.3389/fgene.2019.00986

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Copyright © 2019 Ribeiro, Reyes-Garau, Armengol, Fernández-Serrano and Roué

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Major B-cell non-Hodgkin lymphoma subtypes arise from different cell of origin within the lymph node. Mantle cell lymphomas (MCL) arise from naive B cells or germinal center (GC) B cells found within the mantle zone. Marginal zone lymphomas initiate from naive B cells or GCB that have entered the marginal zone. GCB are the origin of follicular lymphomas (FL), Burkitt lymphoma (BL), and diffuse large B-cell lymphomas (DLBCL) when still in the germinal center. This last DLBCL appears to also form GCB within the marginal zone or from fully developed memory B cells.