Table 1.
Classification of B-cell non-Hodgkin lymphoma.
| Name | Cell of origin | Genetic aberration | Involved genes | Frequency (%) | References |
|---|---|---|---|---|---|
| B-ALL | Hematopoietic stem cell or B-cell progenitor | Hyperdiploidy t(12;21)(p13.2;q22.1) t(1;19)(q23;p13.3) t(9;22)(q34.1;q11.2) |
– ETV6/RUNX1 TCF3/PBX1 BCR/ABL1 |
31* 28* 9* 5* |
(Yeoh et al., 2002) |
| CLL/SLL | Naïve (unmutated IGHV subset) or memory (mutated IGHV subset) B cell | del(13q14.3) – Trisomy of 12 del(11q) |
– SF3B1 – ATM |
54 21 14 12 |
(Haferlach et al., 2007)(Landau et al., 2015) |
| LPL | Post-follicular B cell | – del(6q) – |
MYD88 – CXCR4 ARID1A |
90 43 27 17 |
(Hunter et al., 2014) |
| NMZL | Post-germinal center marginal zone B cell | Gains of 3p Gains of 18q del(6q23) |
– – TNFAIP3 |
24 24 16 |
(Rinaldi et al., 2011) |
| EMZL-MALT | Post-germinal center marginal zone B cell | Trisomy of 3 del(6q23) t(11;18)(q21;q21) Trisomy of 18 |
– TNFAIP3 BIRC3/MALT1 – |
31 30 13 11 |
(Streubel et al., 2004)(Rinaldi et al., 2011) |
| SMZL | Marginal zone B cell with or without antigen exposure | del(7q) Gains of 3q del(17p13) or mutation – |
– – TP53 KLF2 |
26 20 16 12 |
(Rinaldi et al., 2011)(Parry et al., 2015) |
| HCL | Late activated memory B cell | – – |
BRAF MAP2K1 |
100 48 |
(Tiacci et al., 2011)(Waterfall et al., 2013) |
| FL | Germinal center B cell | t(14;18)(q32;q21) – – – |
IGH/BCL2 KMT2D CREBBP TNFRSF14 |
89 82 64 35 |
(Horsman et al., 1995)(Okosun et al., 2014) |
| MCL | Peripheral B cell of the inner mantle zone | t(11;14)(q13;q32) Gain of 3q26 del(11q) or mutation del(17p13) or mutation |
IGH/CCND1 – ATM CCND1 TP53 |
57 49 41 34 27 |
(Beà et al., 1999) (Beà et al., 2013) |
| DLBCL-GCB | Peripheral mature B cell of germinal center origin | – del(1p36) or mutation Gains of 2p16 t(18q21) |
KMT2D TNFRSF14 REL BCL2 |
46 38 30 28 |
(Dubois et al., 2016)(Scholtysik et al., 2015)(Roulland et al., 2018) |
| DLBCL-ABC | Peripheral mature B cell of germinal center exit or post-germinal center | del(9p21) del(6q21) or mutation – – |
CDKN2A PRDM1 KMT2D MYD88 |
47 41 41 28 |
(Scholtysik et al., 2015)(Dubois et al., 2016) |
| BL | Germinal center B cell | t(8;14)(q24;q32) –Other t(8q24) |
MYC/IGH ID3 TCF3 MYC |
77 58 29 8–15 |
(Toujani et al., 2009)(Schmitz et al., 2012) |
*Frequency in pediatric cases. B-ALL, B-cell acute lymphocytic leukemia; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; LPL, lymphoplasmacytic lymphoma; NMZL, nodal marginal zone lymphoma; EMZL-MALT, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; SMZL, splenic marginal zone lymphoma; HCL, hairy cell leukemia; FL, follicular lymphoma; MCL, mantle cell lymphoma; DLBCL-GCB, diffuse large B-cell lymphoma of germinal center B-cell subtype; DLBCL-ABC, diffuse large B-cell lymphoma of activated B-cell subtype; BL, Burkitt lymphoma.