Table 3.
Comparisons of Biomarkers in the Subjects With Different MnSOD1183T>C Genotypes
| MnSOD1183T>C | ||||
|---|---|---|---|---|
| Heavy drinkersa | Nonheavy drinkersb | |||
| TT | TC + CC | TT | TC + CC | |
| Parameters | (n = 88) | (n = 20) | (n = 73) | (n = 33) |
| Hematological test | ||||
| MCV (fl) | 90.5 ± 7.6 | 90.1 ± 5.5 | 87.4 ± 7.3 | 87.5 ± 8.4 |
| Biochemical tests | ||||
| AST (U/l) | 28 ± 19 | 25 ± 7 | 23 ± 8 | 21 ± 6 |
| ALT (U/l) | 33 ± 19 | 32 ± 16 | 31 ± 20 | 29 ± 14 |
| AST/ALT | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.8 ± 0.2 | 0.8 ± 0.2 |
| GGT (U/l) | 52 ± 36 | 54 ± 33 | 28 ± 13 | 27 ± 18 |
| CDT (%) | 1.7 ± 0.6 | 1.9 ± 1.0 | 1.4 ± 0.3 | 1.4 ± 0.5 |
| MDA (μmol/l) | 1.8 ± 1.5 | 1.6 ± 1.4 | 1.5 ± 1.0 | 1.4 ± 0.9 |
| Immunological tests | ||||
| CD3+ cells (%) | 65.8 ± 9.6 | 66.3 ± 8.5 | 62.8 ± 7.8 | 65.7 ± 9.8 |
| CD4+ cells (%) | 36.5 ± 9.3 | 34.3 ± 8.3 | 32.6 ± 7.9 | 30.4 ± 8.5 |
| CD8+ cells (%) | 22.7 ± 6.8 | 21.2 ± 5.2 | 23.4 ± 5.7 | 26.5 ± 7.8* |
| CD19+ cells (%) | 10.8 ± 4.2 | 13.2 ± 4.5* | 12.4 ± 4.5 | 11.1 ± 4.5 |
| IgG (mg/dl) | 1126 ± 227 | 1132 ± 274 | 1209 ± 272 | 1233 ± 202 |
| IgM (mg/dl) | 90 ± 45 | 88 ± 39 | 100 ± 42 | 132 ± 71 |
| IL‐2R (U/l) | 365 ± 129 | 412 ± 166 | 372 ± 157 | 341 ± 114 |
| IL‐6 (ng/ml) | 3.9 ± 2.1 | 4.6 ± 1.9 | 3.5 ± 2.1 | 2.9 ± 1.5 |
| IL‐8 (ng/ml) | 10.4 ± 4.9 | 10.3 ± 5.2 | 9.8 ± 6.6 | 7.9 ± 3.5 |
| IL‐10 (ng/ml) | 1.9 ± 1.1 | 2.1 ± 0.8 | 1.9 ± 1.3 | 1.5 ± 1.0 |
| TNF‐α (pg/ml) | 10.2 ± 8.4 | 7.5 ± 2.3* | 10.6 ± 9.0 | 10.1 ± 9.0 |
a*P <0.05 compared with the subjects with the TT genotypes in the heavy drinkers.
b*P <0.05 compared with the subjects with the TT genotypes in the nonheavy drinkers.
MCV, mean corpuscular volume; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma‐glutamyl transferase; carbohydrate‐deficient transferring; MDA, malondialdehyde; CD, cluster differentiation; Ig, immunoglobulin; IL, interleukin; TNF, tumor necrosis factor.