Table 4.
Comparisons of the Biomarkers in the Subjects With Different Combined Genotypes of MnSOD1183T>C and MPO‐463G>A
| Heavy drinkers | Nonheavy drinkers | |||||||
|---|---|---|---|---|---|---|---|---|
| MnSOD TT | MnSOD TC + CC | MnSOD TT | MnSOD TC + CC | |||||
| MPO | MPO | MPO | MPO | MPO | MPO | MPO | MPO | |
| GG [A] | GA + AA [B] | GG [C] | GA + AA [D] | GG [A] | GA + AA [B] | GG [C] | GA + AA [D] | |
| Parameters | (n = 45) | (n = 43) | (n = 10) | (n = 10) | (n = 50) | (n = 23) | (n = 21) | (n = 12) |
| Immunological tests | ||||||||
| CD3+ cells (%) | 65.7 ± 11.0 | 65.9 ± 7.9 | 65.3 ± 8.4 | 67.3 ± 8.9 | 63.2 ± 7.3 | 62.3 ± 9.4 | 66.4 ± 9.1 | 64.2 ± 10.9 |
| CD4+ cells (%) | 35.7 ± 9.6 | 37.2 ± 9.0 | 30.3 ± 5.7 | 38.3 ± 8.8 | 32.4 ± 8.1 | 33.0 ± 7.6 | 28.4 ± 7.9 | 33.8 ± 8.7 |
| CD8+ cells (%) | 23.0 ± 7.0 | 22.5 ± 6.8 | 21.7 ± 5.0 | 20.7 ± 5.7 | 23.6 ± 6.0 | 23.1 ± 5.1 | 27.0 ± 8.8 | 25.5 ± 6.0 |
| CD19+ cells (%) | 10.5 ± 3.7 | 11.1 ± 4.6 | 10.5 ± 3.8 | 16.0 ± 3.4a , b , c | 12.2 ± 4.8 | 12.8 ± 3.9 | 11.9 ± 4.6 | 9.8 ± 4.2 |
| IgG (mg/dl) | 1118 ± 200 | 1134 ± 255 | 1195 ± 293 | 1071 ± 253 | 1194 ± 248 | 1243 ± 322 | 1234 ± 213 | 1232 ± 191 |
| IgM (mg/dl) | 82 ± 37 | 98 ± 52 | 92 ± 44 | 84 ± 35 | 95 ± 40 | 111 ± 45 | 156 ± 73a , b , d | 90 ± 45 |
| IL‐2R (U/l) | 359 ± 118 | 371 ± 140 | 382 ± 188 | 443 ± 145 | 361 ± 167 | 392 ± 138 | 338 ± 120 | 357 ± 100 |
| IL‐6 (ng/ml) | 3.9 ± 2.0 | 3.8 ± 2.1 | 3.4 ± 1.1 | 5.8 ± 1.9a , b , c | 3.4 ± 2.2 | 3.6 ± 2.0 | 2.9 ± 1.6 | 2.9 ± 1.4 |
| IL‐8 (ng/ml) | 9.8 ± 4.7 | 11.0 ± 5.1 | 8.6 ± 2.8 | 11.9 ± 6.5 | 9.2 ± 5.2 | 9.7 ± 7.3 | 8.8 ± 7.0 | 8.9 ± 3.3 |
| IL‐10 (ng/ml) | 2.0 ± 1.1 | 1.9 ± 1.0 | 2.3 ± 1.1 | 1.8 ± 0.4 | 1.8 ± 1.3 | 2.1 ± 1.2 | 1.3 ± 0.7 | 1.8 ± 1.4 |
| TNF‐α (pg/ml) | 10.9 ± 9.8 | 9.5 ± 6.6 | 6.8 ± 1.8 | 8.2 ± 2.6 | 10.0 ± 9.1 | 11.7 ± 9.0 | 11.3 ± 11.0 | 8.1 ± 2.8 |
The alphabet in the square bracket indicates the group of the study.
a
P <0.05, compared with Group A in the heavy drinkers or nonheavy drinkers, respectively.
b
P <0.05, compared with Group B in the heavy drinkers or nonheavy drinkers, respectively.
c
P <0.05, compared with Group C in the heavy drinkers.
d
P <0.05, compared with Group D in the nonheavy drinkers.
CD, cluster differentiation; Ig, immunoglobulin; IL, interleukin; TNF, tumor necrosis factor.