Table 2.
Genotypic and Allelic Frequencies of SRC‐1 Genetic Polymorphisms in KD Patients With and Without CAA
| KD without CAA | KD with CAA | Normala | ||||||
|---|---|---|---|---|---|---|---|---|
| dsSNP ID | N = 279 (%) | N = 48 (%) | N (%) | P‐valueb | P‐valuec | OR (95% CI)d | OR (95% CI)e | |
| rs11894248 | Genotype | <0.001 | 0.761 | |||||
| TT | 217 (77.8) | 22 (45.8) | 102 (74.5) | Ref | Ref | |||
| TC + CC | 62 (23.3) | 26 (54.2) | 35 (25.5) | 4.14 (2.19–7.80) | 4.07 (2.14–7.76) | |||
| Allele type | <0.001 | 0.774 | ||||||
| T | 493 (88.4) | 68 (70.8) | 237 (86.5) | Ref | Ref | |||
| C | 65 (11.6) | 28 (29.2) | 37 (13.5) | 3.12 (1.88–5.20) | 3.07 (1.82–5.17) | |||
| rs17791703 | Genotype | <0.001 | 0.761 | |||||
| AA | 217 (77.8) | 22 (45.8) | 102 (74.5) | Ref | Ref | |||
| AG + GG | 62 (22.2) | 26 (54.2) | 35 (25.5) | 4.14 (2.19–7.80) | 4.07 (2.14–7.76) | |||
| Allele type | <0.001 | 0.774 | ||||||
| A | 493 (88.4) | 68 (70.8) | 237 (86.5) | Ref | Ref | |||
| G | 65 (11.6) | 28 (29.2) | 37 (13.5) | 3.12 (1.88–5.20) | 3.07 (1.82–5.17) | |||
| rs7572475 | Genotype | <0.001 | 0.729 | |||||
| AA | 217 (77.8) | 22 (45.8) | 103 (74.6) | Ref | Ref | |||
| AT + TT | 62 (22.2) | 26 (54.2) | 35 (25.4) | 4.14 (2.19–7.80) | 4.07 (2.14–7.76) | |||
| Allele type | <0.001 | 0.708 | ||||||
| A | 493 (88.4) | 69 (71.9) | 238 (86.9) | Ref | Ref | |||
| T | 65 (11.6) | 27 (28.1) | 36 (13.1) | 2.97 (1.77–4.97) | 2.92 (1.73–4.94) | |||
| rs9309308 | Genotype | <0.001 | 0.548 | |||||
| TT | 215 (77.1) | 22 (45.8) | 103 (75.2) | Ref | Ref | |||
| TC + CC | 64 (22.9) | 26 (54.2) | 34 (24.8) | 3.97 (2.11–7.47) | 3.86 (2.03–7.35) | |||
| Allele type | <0.001 | 0.540 | ||||||
| C | 68 (12.2) | 28 (29.2) | 238 (86.9) | Ref | Ref | |||
| T | 490 (87.8) | 68 (70.8) | 36 (13.1) | 2.97 (1.79–4.93) | 2.87 (1.71–4.82) |
KD, Kawasaki disease; OR, odds ratio; CI, confidence interval from unconditional logistic regression analysis.
a
Normal population from Han Chinese in Beijing (CHB; data from HapMap database, http://hapmap.ncbi.nlm.nih.gov/).
b
P‐value from chi‐square test; compared KD patients with CAA and without CAA.
c
P value from chi‐square test; compared KD patients with normal population from Han Chinese in Beijing.
d
Unadjusted odd ratio.
e
Odds ratios were estimated adjusting for gender.