Table 3.
Genotypic and Allelic Frequencies of Smad3 Genetic Polymorphism in KD Patients With and Without CAA
| KD without CAA | KD with CAA | Normal | ||||||
|---|---|---|---|---|---|---|---|---|
| dsSNP ID | N = 279 (%) | N = 48 (%) | N (%) | P‐valuea | P‐valueb | OR (95% CI)c | OR (95% CI)d | |
| rs12901071 | Genotype | 0.140 | 0.044 | |||||
| TT | 185 (66.3) | 37 (77.1) | 79 (58.1) | Ref | Ref | |||
| TC + CC | 94 (33.7) | 11 (22.9) | 57 (41.9) | 0.59 (0.29–1.20) | 0.55 (0.26–1.13) | |||
| Allele type | 0.109 | 0.087 | ||||||
| C | 104 (18.6) | 11 (11.5) | 211 (77.6) | Ref | Ref | |||
| T | 454 (81.4) | 85 (88.5) | 61 (22.4) | 0.57 (0.29–1.10) | 0.54 (0.28–1.05) |
KD, Kawasaki disease; OR, odds ratio; CI, confidence interval from unconditional logistic regression analysis.
a
Normal population from Han Chinese in Beijing (CHB; data from HapMap database, http://hapmap.ncbi.nlm.nih.gov/).
b
P‐value from chi‐square test; compared KD patients with CAA and without CAA.
P‐value from chi‐square test; compared KD patients with normal population from Han Chinese in Beijing.
c
Unadjusted odd ratio.
d
Odds ratios were estimated adjusting for gender.