Table 3.
Characterization of Gene Sequences Along with Fold Reduction in MIC Values for Different Antibiotics with β-Lactam Inhibitor and Efflux Pump Inhibitors Among ESBL-Positive Klebsiella pneumoniae Isolates
| Isolates | β-lactamases | Carbapenemase | AZT+CA | AZT+EP1 | AZT+EP2 | CAZ+CA | CAZ+EP1 | CAZ+EP2 | IM+CA | IM+EP1 | IM+EP2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GMCH01 | SHV, CTX-M15 | NDM | 16 | 1 | 2 | 1 | 1 | 1 | 4 | 4 | 1 |
| GMCH02 | TEM, CTX-M15 | NDM | 64 | 4 | 2 | 1 | 1 | 8 | 8 | 4 | 1 |
| GMCH03 | SHV, CTX-M15 | OXA-181, NDM | 512 | 32 | 8 | 1 | 2 | 2 | 1 | 1 | 1 |
| GMCH04 | SHV, CTX-M15 | OXA-181, NDM | 256 | 256 | 16 | 1 | 2 | 2 | 1 | 1 | 1 |
| GMCH07 | SHV, TEM, CTX-M15 | — | 32 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 1 |
| GMCH08 | SHV-1, TEM, CTX-M15 | NDM | 64 | 1 | 1 | 1 | 1 | 1 | 16 | 4 | 2 |
| GMCH09 | SHV-28,TEM, CTX-M15 | NDM | 128 | 2 | 4 | 1 | 2 | 2 | 1 | 2 | 1 |
| GMCH10 | SHV-28, TEM, CTX-M15 | IMP, NDM | 1 | 128 | 2 | 1 | 8 | 2 | 1 | 64 | 2 |
| GMCH11 | SHV, TEM, CTX-M15 | NDM | 2000 | 1 | 2 | 2 | 1 | 4 | 16 | 8 | 4 |
| GMCH12 | SHV, TEM, CTX-M15 | NDM, IMP | 256 | 1 | 1 | 8 | 1 | 2 | 50 | 16 | 8 |
| GMCH13 | SHV, TEM, CTX-M15 | NDM, IMP | 4 | 1 | 1 | 32 | 1 | 1 | 4 | 4 | 4 |
| GMCH15 | SHV, TEM, CTX-M15 | OXA-181 | 1 | 1 | 4 | 1 | 1 | 2 | 4 | 4 | 4 |
| GMCH16 | SHV, TEM, CTX-M15 | NDM | 16 | 16 | 16 | 128 | 2 | 2 | 16 | 1 | 1 |
| GMCH19 | SHV, TEM, CTX-M15 | — | 8 | 4 | 2 | 32 | 4 | 4 | 1 | 1 | 1 |
| GMCH20 | SHV, CTX-M15 | OXA-181, NDM, | 128 | 2 | 4 | 256 | 1 | 4 | 2 | 2 | 2 |
| GMCH1101 | SHV, TEM, CTX-M15 | — | 2053 | 2 | 2 | 512 | 2 | 8 | 16 | 4 | 2 |
| GMCH1249 | SHV, TEM, CTX-M15 | NDM | 4 | 2 | 8 | 2 | 2 | 4 | 32 | 4 | 2 |
| GMCH1144 | SHV, TEM, CTX-M15 | NDM | 128 | 1 | 1 | 64 | 1 | 2 | 8 | 4 | 4 |
| GMCH1143 | SHV, TEM, CTX-M15 | NDM | 8 | 1 | 1 | 4 | 1 | 2 | 4 | 2 | 1 |
| GMCH490 | SHV, TEM, CTX-M15 | — | 128 | 1 | 2 | 128 | 2 | 2 | 4 | 2 | 1 |
| GMCH827 | SHV, CTX-M15 | IMP, NDM | 32 | 8 | 1 | 253 | 2 | 2 | 16 | 8 | 2 |
| GMCH1428 | SHV, TEM, CTX-M15 | — | 128 | 8 | 4 | 4 | 2 | 1 | 64 | 4 | 1 |
| GMCHB8 | SHV-55, TEM | NDM | 64 | 1 | 2 | 2 | 1 | 2 | 128 | 1 | 1 |
| GMCH1573 | CTX-M15 | NDM | 128 | 0.5 | 4 | 128 | 1 | 1 | 1 | 1 | 1 |
| GMCH976 | SHV, TEM, CTX-M15 | NDM | 256 | 8 | 16 | 1 | 2 | 4 | 8 | 8 | 2 |
| GMCH1522 | SHV, CTX-M15 | IMP, NDM | 8 | 4 | 2 | 8 | 1 | 1 | 2 | 1 | 1 |
| GMCH1243 | CTX-M15 | — | 128 | 1 | 1 | 1 | 1 | 1 | 0.5 | 1 | 0.5 |
| GMCH8941 | SHV, TEM, CTX-M15 | IMP | 32 | 2 | 1 | 64 | 2 | 2 | 8 | 4 | 2 |
| GMCH14543 | CTX-M15 | — | 16 | 2 | 1 | 8 | 16 | 1 | 8 | 4 | 1 |
| GMCH7708 | CTX-M15 | — | 32 | 8 | 2 | 8 | 8 | 1 | 4 | 8 | 1 |
| GMCH14114 | CTX-M15 | NDM | 32 | 1 | 4 | 32 | 1 | 1 | 8 | 1 | 1 |
| GMCH8006 | TEM, CTX-M15 | NDM | 128 | 2 | 1 | 16 | 1 | 1 | 32 | 8 | 4 |
| GMCH7662 | CTX-M15 | NDM | 513 | 2 | 4 | 128 | 2 | 4 | 64 | 16 | 8 |
The MIC fold reduction ≥8-fold is highlighted in gray.
AZM, Aztreonam; CA, potassium clavulanic acid (16 μg/mL); CAZ, ceftazidime; IM, imipenem; EP1, CCCP (16 μg/mL); EP2, PAβN (25 μg/mL).