Table 1.

Pharmacokinetic parameters of ertapenem in sheep after single dosing

Parameter	Unit	Geometric mean	Median	Minimum	Maximum
Cmax	µg/mL	228.1	216.5	182	324
T1/2 (λz)	h	1.09	1.13	0.65	2.7
AUClast	(µg/mL)×h	142.0	146.5	112.3	176.7
Clearance	mL/h/kg	108.3	109.1	131.4	81.2
AUMC	(µg/mL)×h2	97.3	97.1	73.4	137.9
Mean residence time	h	0.69	0.70	0.55	0.78
Volume of distribution at steady state	mL/kg	76.8	78.1	52.7	113.4
Clast	µg/mL	0.28	0.3	0.125	0.7
Tlast	h	5.9	6	4	8
λz	1/h	0.59	0.61	0.25	1.06