Table 3.
Summary of JTK_CYCLE analysis for mice maintained in control CWF and experimental bLAD lighting environments
| Estimated Peak Phasea |
Phase Shiftb (hrs) | Amplitudea |
Fold Changeb | Q-value for Circadian Cyclinga |
||||
| CWF | bLAD | CWF | bLAD | CWF | bLAD | |||
| C3H mice | ||||||||
| Corticosterone | 18:00 | 18:00 | 0 | 3.72E-05 | 2.27E-05 | 1.64 | NS | 2.85E-02 |
| Glucose | 14:00 | 14:00 | 0 | 5.41 | 4.90E-05 | 1.10E+05 | 4.55E-05 | 8.29E-11 |
| Insulin | 2:00 | 4:00 | +2 | 1.94 | 2.20 | −1.13 | 7.11E-08 | 1.46E-04 |
| Lactate | 12:00 | 18:00 | +6 | 0.00 | 5.80E-02 | — | 1.29E-03 | 3.05E-04 |
| Leptin | 22:00 | 24:00 | +2 | 0.67 | 0.51 | 1.32 | 7.11E-08 | 2.30E-10 |
| Melatonin | 02:00 | 02:00 | 0 | 36.94 | 113.06 | −3.06 | 8.29E-11 | 2.60E-14 |
| pCO2 | NEd | 22:00 | — | NEe | 0.64 | — | 8.20E-04 | NS |
| pO2 | 14:00 | 14:00 | 0 | 7.78 | 3.89 | 2.00 | 2.97E-10 | 1.86E-06 |
| TFA | 04:00 | 04:00 | 0 | 1328.09 | 982.88 | 1.35 | 2.43E-22 | 2.43E-22 |
| C57BL/6 mice | ||||||||
| Corticosterone | 1800 | NEd | — | 2.18E–05 | NEe | — | 4.42E–02 | 2.42E–01 |
| Glucose | 1400 | 1400 | 0 | 5.05 | 5.24 | −1.04 | 2.77E–05 | 5.22E–05 |
| Insulin | 0200 | 0200 | 0 | 1.91 | 1.90 | 1.00 | 2.22E–09 | 1.32E–09 |
| Lactate | 1400 | 1400 | 0 | 0.04 | 0.03 | 1.17 | 7.40E–03 | 1.49E–02 |
| Leptin | 2200 | 2200 | 0 | 0.70 | 0.70 | 1.00 | 7.11E–08 | 7.11E–08 |
| Melatonin | NEd | 1000 | — | NEe | 0.16 | — | NS | NS |
| pCO2 | 1400 | 1400 | 0 | 9.86E–06 | 0.16 | −1.66E+04 | 3.95E–03 | 5.97E–03 |
| pO2 | 1400 | 1400 | 0 | 8.49 | 7.78 | 1.09 | 1.41E–12 | 1.09E–13 |
| TFA | 0400 | 0400 | 0 | 719.97 | 700.74 | 1.03 | 1.33E–20 | 4.73E–21 |
| BALB/c mice | ||||||||
| Corticosterone | NEd | 1800 | — | NEe | 3.23E–05 | — | NS | 1.91E–02 |
| Glucose | 1400 | 1400 | 0 | 5.47 | 5.87 | −1.07 | 4.55E–05 | 3.78E–05 |
| Insulin | 0200 | 0200 | 0 | 1.88 | 1.87 | 1.01 | 7.04E–10 | 9.00E–10 |
| Lactate | NEd | 1400 | — | NEd | 0.03 | — | 1.44E–02 | 5.24E–03 |
| Leptin | 0200 | 0200 | 0 | 0.60 | 0.66 | −1.11 | 2.07E–11 | 6.13E–12 |
| Melatonin | 1000 | 0200 | +8 | 0.34 | 37.32 | −109.47 | NS | 6.82E–13 |
| pCO2 | 1400 | 1400 | 0 | 5.00E–15 | 0.07 | −1.42E+13 | 5.97E–03 | 2.29E–03 |
| pO2 | 1400 | 1400 | 0 | 7.78 | 8.49 | −1.09 | 2.06E–10 | 2.99E–14 |
| TFA | 0400 | 0400 | 0 | 1156.38 | 1074.34 | 1.08 | 2.43E–22 | 2.92E–17 |
NS, not significant
a
Phase-, amplitude-, and multiple-testing-adjusted P value (Q) estimated by using JTK_CYCLE analysis with a fixed 24-h period and original units described in the text.
b
Phase difference and fold change are for the bLAD group relative to the the CWF group. A decrease in bLAD amplitude with regard to CWF is a negative value; an increase is represented by a positive value.
c
NE, not estimated (JTK_CYCLE analysis did not converge on a single peak phase or amplitude; a value was not provided)