. 2019 Oct 16;35(1):21–30. doi: 10.1080/14756366.2019.1677638

Table 2.

Biological data and docking scores achieved for compounds of the set.

Compound	K_ITcCA (nM)	K_I hCA II (nM)^a	Selectivity ratio	Docking score	% Proliferation. Epimastigotes^b		% Viability. Trypomastigotes 24 h^c
Compound	K_ITcCA (nM)	K_I hCA II (nM)^a	Selectivity ratio	Docking score	3rd day of growth	7th day of growth	% Viability. Trypomastigotes 24 h^c
1	594.4	>10,000	>16.8	−8.38	86	92	73
2	604.6	>10,000	>16.5	−9.16	79	102	66
3	752.5	4957	>6.6	−9.30	107	94	91
4	950.5	>10,000	>10.5	−8.48	57	55	72
5	261.4	8528	>32.6	−9.13	73	96	105
6	951.8	>10,000	>10.5	−8.14	103	104	65
7	7250	8884	1.22	−8.79	103	121	76
8	448.8	>10,000	>22.3	−7.97	72	114	98
Acesulphame	2242	>20,000	>8.9	−7.05	92	89	101
Sodium cyclamate	348.1	>10,000	>28.7	−7.46	89	78	52

^aInhibition constants against hCAII were taken from literature^28–30.

^bEpimastigotes of the Y strain of T. cruzi (candidates tested at 50 µM).

^cTrypomastigotes of the RA strain of T. cruzi (candidates tested at 20 µM).