Figure 7.

Cone photoreceptor cell labeling in retinas of rd10 mice administered (+)-PTZ versus rd10 nontreated mice over 180 days. The rd10 mice were treated every other day with/without (+)-PTZ beginning at P14. Eyes were harvested and processed for cryosectioning and immunodetection of FITC-PNA to detect cone photoreceptor cells. Representative retinal cross sections of PNA labeling in rd10 nontreated and rd10+PTZ mice for (A) P60, (B) P90, (C) P120, and (D) P180. Arrows point to cells that label positively for PNA (green fluorescence). Note that the insets associated with (B, C) show enlarged images of PNA-positive cells at P90 and P120, respectively, for the rd10+PTZ retina. DAPI-stained nuclei are labeled blue.