Table 1.

Cortical Geometry and Trabecular Microarchitecture in Adult and Aged Control and Loaded Tibias by µCT

	Adult control (n = 5)	Adult loaded (n = 5)	Aged control (n = 8)	Aged loaded (n = 8)
Cortical geometry
Cortical area (mm2)	0.741 ± 0.028	0.775 ± 0.019a	0.698 ± 0.037	0.698 ± 0.035
Total area (mm2)	1.144 ± 0.059	1.202 ± 0.019	1.254 ± 0.053	1.307 ± 0.092
Marrow area (mm2)	0.0045 ± 0.0011	0.0042 ± 0.0021	0.0047 ± 0.0017	0.0048 ± 0.0008
Cortical thickness (mm)	0.2264 ± 0.0040	0.2306 ± 0.0051	0.1840 ± 0.0145b	0.1919 ± 0.0089
Imax (mm4)	0.1290 ± 0.0069	0.1411 ± 0.0075c	0.1432 ± 0.0186	0.1559 ± 0.0206d
Imin (mm4)	0.0713 ± 0.0105	0.0799 ± 0.0053e	0.0794 ± 0.0066	0.0838 ± 0.0088
pMOI (mm4)	0.2011 ± 0.0128	0.2201 ± 0.0075f	0.2236 ± 0.0232	0.2386 ± 0.0272g
Trabecular microarchitecture
BV/TV (%)	2.992 ± 1.002	2.866 ± 0.818	0.894 ± 0.683h	0.826 ± 0.642
Trabecular number (1/mm)	2.407 ± 0.187	2.295 ± 0.206	1.285 ± 0.337b	1.298 ± 0.295
Trabecular thickness (mm)	0.0461 ± 0.0029	0.0448 ± 0.0033	0.0550 ± 0.0094	0.0532 ± 0.0097
Trabecular spacing (mm)	0.4180 ± 0.0364	0.4444 ± 0.0395	0.8453 ± 0.2469i	0.8190 ± 0.1907
Connectivity density (1/mm3)	7.145 ± 5.043	6.963 ± 5.449	2.298 ± 5.294	1.768 ± 3.773
SMIc	3.479 ± 0.335	3.356 ± 0.223	3.119 ± 0.305	2.980 ± 0.521

Imax = maximum area moment of inertia; Imin = minimum area moment of inertia; pMOI = polar moment of inertia; BV/TV = bone volume/total volume; SMI = structure model index.

Loaded versus age‐matched controls: ^a p = 0.0005; ^c p = 0.0225; ^d p = 0.0040; ^e p = 0.0163; ^f p = 0.0044; ^g p = 0.0045.

Aged versus adult controls: ^b p < 0.0001; ^h p = 0.002; ⁱ p = 0.0007.