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. 2019 Aug 23;3(9):e10201. doi: 10.1002/jbm4.10201

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© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Pathway analysis of 50 genes involved in bone metabolism from RNA‐sequencing data of control and PPA‐treated (0.5 mg/kg/day) animals with at least a 1.5‐fold change in expression. (A) Top 15 overall enriched pathways: 68% (34 genes); 64% (32 genes); and 56% (28 genes) are the top three groups of genes involved in biological regulation, multicellular organismal process, and development process, respectively. (B) Top 15 bone related pathways: 32% (16 genes) and 24% (12 genes) are involved in anatomical structure morphogenesis and skeletal system development, respectively.