Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 23;3(9):e10201. doi: 10.1002/jbm4.10201

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

RNA‐sequencing data of significantly fold‐changed genes possibly involved in bone formation or resorption in bone between two treatment groups. (A) Principal component analysis of predicted functional metagenomics pathways of all 550 bone‐related genes and 1.5‐fold changed 50 bone‐related genes using the PICRUSt bioinformatics software package. (B) Heat map of 1.5‐fold changed 50 bone‐related genes representing three pools (control 1, 2, 3 versus 0.5 mg/kg/day PPA treatment 1, 2, 3). (C) Real‐time PCR confirms gene expression of Ctsk and MMP9 (plus p53 and Runx2 were not included in the list) between two groups. Significant differences indicated by p < 0.05, *0.5 mg/kg/day PPA treatment compared to either control. Ctsk = cathepsin K.