Table 1.
Trabecular and Cortical µCT Parameters on Tibias of Control or PPA‐Treated Mice
| Female mice PPA (mg/kg/day) | |||||
|---|---|---|---|---|---|
| 0 | 0.1 | 0.5 | 1 | 5 | |
| Trabecular | |||||
| BV/TV | 0.18 ± 0.008 | 0.21 ± 0.005* | 0.20 ± 0.006* | 0.20 ± 0.006* | 0.20 ± 0.009 |
| Connectivity density | 209.5 ± 23.4 | 259.8 ± 26.6* | 234.1 ± 9.6* | 229.9 ± 14.0* | 239.3 ± 16.8* |
| SMI | 1.98 ± 0.04 | 1.64 ± 0.06* | 1.64 ± 0.08* | 1.80 ± 0.1 | 1.73 ± 0.06* |
| Tb.N | 4.91 ± 0.24 | 5.14 ± 0.12 | 4.83 ± 0.16 | 5.02 ± 0.07 | 4.89 ± 0.11 |
| Tb.Th | 0.049 ± 0.0003 | 0.051 ± 0.0007* | 0.055 ± 0.002* | 0.053 ± 0.002* | 0.053 ± 0.0009* |
| Tb.Sp | 0.21 ± 0.011 | 0.20 ± 0.006* | 0.21 ± 0.01 | 0.20 ± 0.003* | 0.21 ± 0.005 |
| vBMD | 719.8 ± 10.2 | 681.3 ± 8.4* | 690.7 ± 6.0* | 700.1 ± 5.0 | 713.2 ± 9.6 |
| Cortical | |||||
| Cortical CSA | 0.198 ± 0.004 | 0.189 ± 0.004 | 0.197 ± 0.004 | 0.197 ± 0.005 | 0.20 ± 0.004 |
| Cortical thickness | 0.164 ± 0.003 | 0.162 ± 0.003 | 0.161 ± 0.005 | 0.163 ± 0.002 | 0.167 ± 0.003 |
| Total CSA | 0.40 ± 0.008 | 0.38 ± 0.007 | 0.40 ± 0.01 | 0.40 ± 0.02 | 0.40 ± 0.01 |
| Periosteal perimeter | 1.50 ± 0.02 | 1.46 ± 0.02 | 1.55 ± 0.07 | 1.50 ± 0.04 | 1.51 ± 0.03 |
| Midshaft diameter | 0.52 ± 0.005 | 0.51 ± 0.006 | 0.50 ± 0.01 | 0.52 ± 0.01 | 0.52 ± 0.006 |
| Medullary area | 0.17 ± 0.006 | 0.16 ± 0.004 | 0.17 ± 0.009 | 0.17 ± 0.01 | 0.17 ± 0.01 |
| Endosteal perimeter | 0.99 ± 0.02 | 0.95 ± 0.02 | 1.04 ± 0.07 | 0.99 ± 0.03 | 0.97 ± 0.04 |
µCT measurements of trabecular and cortical of the tibial bone were evaluated using a Scanco µCT scanner (CT‐40; Scanco Medical AG, Bassersdorf, Switzerland) at 6 m isotropic voxel size with an X‐ray source at power 55 kV, current 145 A, and integration time 300 ms.
PPA = 3‐(3‐hydroxyphenyl) propionic acid; vBMD = volumetric bone mineral density.
*
p < 0.05 versus 0 mg/kg/d, n = 10.