Table 2.
Bone Formation Markers in Serum and Bone Marrow Plasma of Control or PPA‐Treated Mice
| Female mice | |||||
|---|---|---|---|---|---|
| 0 | 0.1 | 0.5 | 1 | 5 | |
| Serum | |||||
| ALP (µUnits/min) | 0.529 ± 0.017 | 0.596 ± 0.0.024* | 0.596 ± 0.029* | 0.593 ± 0.015* | 0.581 ± 0.019* |
| Gla‐OC (ng/mL) | 83.1 ± 24.4 | 147.4 ± 23.1* | 176.7 ± 8.5* | 177.9 ± 9.0* | 176.4 ± 13.0* |
| Bone marrow plasma | |||||
| ALP (µUnits/min) | 0.269 ± 0.026 | 0.489 ± 0.067* | 0.444 ± 0.059* | 0.356 ± 0.050* | 0.580 ± 0.139* |
| Gla‐OC (ng/mL) | 69.8 ± 4.3 | 89.8 ± 8.0* | 84.1 ± 6.1* | 87.7 ± 2.7* | 90.3 ± 4.5* |
| Glu‐OC (ng/mL) | 13.43 ± 0.90 | 36.99 ± 8.23* | 27.02 ± 3.91* | 16.57 ± 1.80 | 15.90 ± 1.98 |
PPA = 3‐(3‐hydroxyphenyl) propionic acid; Gla‐OC = total osteocalcin; Glu‐OC = undercarboxylated osteocalcin; EIA = enzyme immunoassay.
*
p < 0.05 versus 0 mg/kg/day, n = 10; EIA kit from Takara Bio.