Table 1. Comparison of clinicopathological characteristics of breast cancer in various clinical settings.
| Comparison 1 | Comparison 2 | Comparison 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| BC/TC n/N(%) | BC-only n/N(%) | P value | BC-1st n/N(%) | BC-only n/N(%) | P value | TC-1st n/N(%) | BC-only n/N(%) | P value | |
| Number of cases | 2553 | 51060 | 1188 | 27324 | 1364 | 36828 | |||
| BC diagnosis pre-1990 | 480 | 9600 | 321 | 7383 | 159 | 4293 | |||
| BC diagnosis after1990 | 2073 | 41460 | 867 | 19941 | 1205 | 32535 | |||
| Age at diagnosis(yrs), Median (IQR) | 57 (48–67) | 57 (48–67) | 1.000 | 54 (46–63) | 54 (46–63) | 1.000 | 60 (51–70) | 60 (51–70) | 1.000 |
| Tumor Size(mm),Median (IQR) | 16 (10–25) | 17 (11–28) | <0.001 | 16 (10–25) | 18 (11–28) | 0.001 | 15 (10–25) | 17 (10–27) | <0.001 |
| Pathology Ductal | 2044/2553 (80.1) |
40706/51060 (79.7) | 0.685 | 969/1188 (81.6) | 21918/27324 (80.2) | 0.252 | 1074/1364 (78.7) |
29156/36828 (79.2) | 0.711 |
| Lobular | 208/2553 (8.1) |
3927/51060 (7.7) |
0.404 | 86/1188 (7.2) |
1876/27324 (6.9) |
0.619 | 122/1364 (8.9) |
3102/36828 (8.4) |
0.490 |
| Mixed | 212/2553 (8.3) |
4072/51060 (8.0) |
0.552 | 83/1188 (7.0) |
1906/27324 (7.0) |
0.988 | 129/1364 (9.5) |
3195/36828 (8.7) |
0.305 |
| Inflammatory | 11/2553 (0.4) |
328/51060 (0.6) |
0.251 | 6/1188 (0.5) |
199/27324 (0.7) |
0.373 | 5/1364 (0.4) |
207/36828 (0.6) |
0.456 |
| ER/PR status ER-positive | 1551/1901 (81.6) |
30135/38501 (78.3) | 0.001 | 628/788 (79.7) |
13785/18337 (75.2) | 0.004 | 922/1112 (82.9) |
24421/30466 (80.2) | 0.025 |
| PR-positive | 1334/1877 (71.1) |
25941/38194 (67.9) | 0.004 | 548/776 (70.6) |
11890/18144 (65.5) | <0.001 | 785/1100 (71.4) |
20955/30251 (69.3) | 0.144 |
| Both positive | 1299/1876 (69.2) |
25126/38161 (65.8) | 0.002 | 528/776 (68.0) |
11424/18130 (63.0) | 0.005 | 770/1099 (70.1) |
20443/30241 (67.6) | 0.088 |
| LN metastasis | 737/2277 (32.4) |
16323/45201 (36.1) | <0.001 | 333/1009 (33.0) | 8751/22802 (38.4) |
0.001 | 404/1267 (31.9) |
11767/34207 (34.4) | 0.067 |
| Distant Metastasis | 82/2516 (3.3) |
3491/50134 (7.0) |
<0.001 | 36/1168 (3.1) |
1864/26726 (7.0) |
<0.001 | 46/1347 (3.4) |
2438/36284 (6.7) |
<0.001 |
| AJCC Stage I+II | 1762/2059 (85.6) |
33648/41535 (81.0) | <0.001 | 734/862 (85.2) |
16089/20259 (79.4) | <0.001 | 1027/1196 (85.9) | 26406/32267 (81.8) | <0.001 |
| III+IV | 297/2059 (14.4) |
7887/41535 (19.0) | 128/862 (14.8) |
4170/20259 (20.6) |
169/1196 (14.1) | 5861/32267 (18.2) |
|||
| Radiation Therapy | 1211/2498 (48.5) |
25008/49691 (50.3) | 0.074 | 555/1167 (47.6) | 12688/26648 (47.6) | 0.970 | 656/1330 (49.3) | 18681/35823 (52.1) | 0.044 |
| BC-specific Mortality | 288/2553 (11.3) |
10743/51060 (21.0) | <0.001 | 118/1188 (9.9) |
7217/27324 (26.4) |
<0.001 | 169/1364 (12.4) | 6218/36828 (16.9) |
<0.001 |
| Follow Up Time; Median (IQR) | 102 (44–188) |
80 (35–156) |
<0.001 | 155 (82–240) |
102 (49–188) |
<0.001 | 65 (29–135) |
63 (26–130) |
0.152 |
| With Insurance | 801/809 (99.0) |
15987/16182 (98.8) |
0.699 | 225/229 (98.3) |
5149/5214 (98.8) |
0.719 | 575/579 (99.3) |
15525/15712 (98.8) |
0.3683 |
| Married | 1629/2455 (66.4) |
30217/49129 (61.5) |
<0.001 | 784/1142 (68.7) |
16951/26390 (64.2) |
0.003 | 845/1312 (64.4) |
21028/35263 (59.6) |
<0.001 |
| Unemployed* | 115/1513 (7.6) |
2335/30244 (7.7) |
0.904 | 40/575 (7.0) |
945/13217 (7.1) |
0.926 | 74/937 (7.9) |
2048/25286 (8.1) |
0.872 |
| Education (at least bachelor degree)* | 467/1513 (30.9) |
9439/30244 (31.2) |
0.800 | 173/575 (30.1) |
3988/13217 (30.2) |
0.971 | 294/937 (31.4) |
8043/25286 (31.8) |
0.808 |
| Median family income (US dollar); median (IQR) | 65540 (51440–80740) |
65860 (51650–80620) |
0.863 | 60550 (46610–79600) |
60550 (48010–75540) |
0.740 | 66610 (53000–82690) |
66610 (53000–81810) |
0.868 |
Abbreviations: BC, breast cancer; TC, thyroid cancer; BC-only, patients only with breast cancer and without a history of thyroid cancer; BC/TC, breast cancer patients also with a history of thyroid cancer diagnosed any time—either before or after the diagnosis of breast cancer; BC-1st, breast cancer was diagnosed first, followed by subsequent diagnosis of thyroid cancer; TC-1st, thyroid cancer was diagnosed first, followed by subsequent diagnosis of breast cancer; IQR, interquartile range; ER, estrogen receptor; PR, progesterone receptor; LN, lymph node. *The numbers of unemployed cases and cases with an education of least bachelor degree were obtained by calculation based on the unemployment rates and rates of education of at least bachelor degree and the corresponding total cases, respectively, in different counties.