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. 2019 Sep 18;8:e44205. doi: 10.7554/eLife.44205

Table 1. Relevant quantities of influenza virus and parameters in multi-strain SIR model.

Symbol Definition Typical values for influenza Range in simulations
Ia Fraction of population infected with strain a
Sa Population average susceptibility to strain a ∼0.5
Itot=aIi Total prevalence
I¯ Average total prevalence 0.005
d Cross-immunity range [50, 200]
β=νR0 Transmission rate ∼0.5/day 2
ν Recovery rate ∼0.2/day 1 (sets unit of time)
γ Host birth/death rate ∼0.01/year 0
Kab=e-|b-a|/d Cross-immunity of strains a, b
τsw Coalescent time scale/sweep time ∼2-6 years
TMRCA Time to most recent common ancestor ∼2-10 years
δT Fluctuations of TMRCA ∼2-6 years
s Selection coefficient ∼0.03/week [0.003, 0.05]
m Beneficial mutation rate per genome 10-3/week [10-7,10-3]
Nh Host population 1010 [106, 1012]