Table. Characteristics of cases of treatment failure resulting from concurrent infection with mixed strains of drug-resistant Mycobacterium tuberculosis*.
| Patient age, y/sex | Immune status | Site(s) of infection | Time to recurrence | Platform for strain identification | Patient country of origin | Country of diagnosis | Reference |
|---|---|---|---|---|---|---|---|
| 24/M |
Immunocompetent |
Lymph node, gastric aspirate |
100 d |
Mixed-linker fingerprint PCR |
Nepal |
Germany |
(1) |
| 23/M |
HIV negative |
Pulmonary |
150 d |
Spoligotyping and MIRU |
Somalia |
USA |
(4) |
| 24/M |
HIV negative |
Pulmonary, gastric aspirate |
90 d |
IS6110 RFLP and spoligotyping |
Kazakhstan |
Germany |
(2) |
| 62/M |
HIV negative |
Pulmonary |
120 d |
MIRU-VNTR |
Portugal |
UK |
(3) |
| 28/M | HIV positive | Lymph node, trachea | 84 d | Spoligotyping and WGS | Philippines | USA | This study |
*IS, insertion sequence; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; RFLP, restriction fragment length polymorphism; WGS, whole genome sequencing.