Table 1. Characteristics of infants <3 months of age with invasive GBS disease, by disease onset, China, January 1, 2015–December 31, 2017*.
| Characteristics | Early-onset disease, n = 146 | Late-onset disease, n = 158 | Total, n = 304 |
|---|---|---|---|
| Median age at diagnosis, mo (IQR) |
0 (0–1) |
21(15–46) |
8 (0–22) |
| Sex | |||
| M | 74 (50.7) | 64 (40.5) | 138 (45.4) |
| F |
72 (49.3) |
94 (59.5) |
166 (54.6) |
| Birth weight, g | |||
| Median (IQR) | 3,175 (2,700–3,500) | 3,185 (2,800–3,500) | 3,185 (2,725–3,500) |
| 1,500–2,500 | 26 (17.8) | 21(13.3) | 47 15.5) |
| <1,500 |
5 (3.4) |
8 (5.1) |
13 (4.3) |
| Site of delivery | |||
| Sentinel hospital | 115 (78.8) | 84 (53.2) | 199 (65.5) |
| Other hospital |
31 (21.2) |
74 (46.8) |
105 (34.5) |
| Median gestational age, wk (IQR) | 39 (36–40) | 39 (37–40) | 39 (37–40) |
| <34 | 17 (11.6) | 13 (8.2) | 30 (9.9) |
| 34–37 | 22 (15.1) | 19 (12.0) | 41 (13.5) |
| ≥37 |
107 (73.3) |
126 (79.8) |
233 (76.6) |
| Delivery type | |||
| Vaginal | 97 (66.4) | 94 (59.5) | 191 (62.8) |
| C-section | 40 (27.4) | 62 (39.2) | 102 (33.6) |
| Forceps | 7 (4.8) | 1 (0.6) | 8 (2.6) |
| Unknown |
2 (1.4) |
1 (0.6) |
3 (1.0) |
| Specimen type | |||
| Blood | 107 (73.3) | 78 (49.4) | 185 (60.9) |
| Cerebrospinal fluid | 5 (3.4) | 19 (12.0) | 24 (7.9) |
| Blood and cerebrospinal fluid |
34 (23.3) |
61 (38.6) |
95 (31.2) |
| Bacterial infections† | |||
| Sepsis | 122 (83.6) | 121 (76.6) | 243 (79.9) |
| Pneumonia‡ | 76 (52.1) | 50 (31.7) | 126 (41.4) |
| Meningitis | 18 (12.3) | 69 (43.7) | 87 (28.6) |
| Sepsis and pneumonia | 62 (42.5) | 35 (22.2) | 97 (31.9) |
| Sepsis and meningitis | 7 (4.8) | 43 (27.2) | 50 (16.4) |
| Pneumonia and meningitis |
2 (1.4) |
2 (1.3) |
4 (1.3) |
| Clinical symptoms† | |||
| Fever | 38 (26.0) | 121 (76.6) | 159 (52.3) |
| Breathing problems | 83 (56.9) | 38 (24.1) | 121 (39.8) |
| Cyanosis | 32 (21.9) | 10 (6.3) | 42 (13.8) |
| Seizures | 4 (2.7) | 20 (12.7) | 24 (7.9) |
| Limpness or stiffness | 5 (3.4) | 10 (6.3) | 15 (4.9) |
| Poor feeding | 13 (8.9) | 27 (17.1) | 40 (13.2) |
| Irritability |
4 (2.7) |
15 (9.5) |
19 (6.3) |
| Median length of hospitalization, d (IQR) |
15 (12–19) |
18 (13–32) |
16 (12–26) |
| Discharge outcome | |||
| Recovered | 105 (71.9) | 100 (63.3) | 205 (67.4) |
| Transferred to other hospitals | 4 (2.7) | 13 (8.2) | 17 (5.6) |
| Died | 4 (2.7) | 3 (1.9) | 7 (2.3) |
| Abnormal neurology at discharge | 5 (3.4) | 12 (7.6) | 17 (5.6) |
| Condition improved | 12 (8.2) | 16 (10.1) | 28 (9.2) |
| Discharge requested | 16 (11.0) | 14 (8.9) | 30 (9.9) |
*Values are no. (%) except as indicated. GBS, group B Streptococcus; IQR, interquartile range. †Cases could have >1. ‡As assessed by attending physician by using criteria from Zhu Futang Practice of Pediatrics (11).