Table 6. Summary of impairment and death at day 90 after randomization for patients with confirmed West Nile virus in study of treatments for West Nile virus central nervous system disease, by treatment arm* .
Instrument | Omr-IgG-am, n = 33 | Polygam, n = 11 | Normal saline, n = 11 | Total, n = 55 |
---|---|---|---|---|
Modified Mini-Mental Status Examination | ||||
Normal, score >88 | 14 (42.4) | 6 (54.5) | 8 (72.7) | 28 (50.9) |
Mild/moderately impaired but independent, score 78–88 | 8 (24.2) | 0 | 2 (18.2) | 10 (18.2) |
Severely impaired, score <78 | 5 (15.2) | 1 (9.1) | 1 (9.1) | 7 (12.7) |
Dead, score 0 | 2 (6.0) | 3 (27.3) | 0 | 5 (9.1) |
Not done/lost to follow-up |
4 (12.1) |
1 (9.0) |
0 |
5 (9.1) |
Barthel Index | ||||
Normal, score >94 | 15 (45.5) | 5 (45.5) | 6 (54.5) | 26 (47.3) |
Mild/moderately impaired but independent, score 90–94 | 1 (3.0) | 0 | 2 (18.2) | 3 (5.5) |
Severely impaired, score <90 | 11 (33.3) | 2 (18.2) | 3 (27.3) | 16 (29.1) |
Dead, score 0 | 2 (6.1) | 3 (27.3) | 0 | 5 (9.1) |
Not done/lost to follow-up |
4 (12.1) |
1 (9.0) |
0 |
5 (9.1) |
Glasgow Outcome Score | ||||
Normal, score 5 | 10 (30.3) | 3 (27.3) | 7 (63.6) | 20 (36.4) |
Mild/moderately impaired but independent, score 4 | 9 (27.2) | 2 (18.2) | 1 (9.1) | 12 (21.8) |
Severely impaired, score 2–3 | 9 (27.2) | 3 (27.3) | 3 (27.3) | 15 (27.3) |
Dead, score 1 | 2 (6.0) | 3 (27.3) | 0 | 5 (9.1) |
Not done/lost to follow-up |
3 (9.0) |
0 |
0 |
3 (5.5) |
Modified Rankin Scale | ||||
Normal, score 0 | 4 (12.1) | 0 | 4 (36.4) | 8 (14.5) |
Mild/moderately impaired but independent, score 1–3 | 15 (45.5) | 5 (45.5) | 4 (36.4) | 24 (43.6) |
Severely impaired, score 4–5 | 10 (30.3) | 3 (27.3) | 3 (27.3) | 16 (29.1) |
Dead, score 6 | 2 (6.0) | 3 (27.3) | 0 | 5 (9.1) |
Not done | 2 (6.0) | 0 | 0 | 2 (3.6) |
*Values are no. (%) patients. In comparing Omr-IgG-am with Polygam and Omr-IgG-am with normal saline, we found no significant differences with respect to the impairment and death categories (excluding “not done”) for all instruments listed on this table (p > 0.05 for all values).