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. 2019 Oct 23;5(10):eaax7142. doi: 10.1126/sciadv.aax7142

Fig. 5. ZIKV infection impairs DHA uptake and lipid homeostasis.

Fig. 5

(A) Heat map representation of the percentage of individual phospholipid species in hBMECs. The hBMECs were infected with the ZIKV SZ01 strain at an MOI of 1 for 48 hours. Mock-infected hBMECs were used as the NC. Cells were harvested for lipidomic analysis. DHA-containing phospholipid species are highlighted in red. Each group includes three experimental repeats. Ctrl, control. (B) Lipidomic analysis of the total DHA levels and DHA-containing phospholipid species in mock- or ZIKV-infected hBMECs. The results are representative of three independent experiments. The value for each species is normalized against the total peak areas. (C and D) In vivo lipidomic analysis with ZIKV-infected neonatal mouse brains. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, by one-way analysis of variance (ANOVA).