Table 4.

Odds ratio (OR) (95% CI) for the associations of biomarkers with ultrasound-detected abdominal aortic aneurysms (AAA) in the Atherosclerosis Risk in Communities (ARIC) study, 1987 to 2013.

Biomarkers	Tertile 1	Tertile 2	Tertile 3	p for trend
MMP-3
Median (range), pg/mL	6413 (2364, 8392)	10572 (8399, 12526)	15808 (12702, 38099)
n	99	100	100
n AAA	23	23	26
Odds Ratio (95% CI)
Model 1	1	0.83 (0.38, 1.82)	1.25 (0.55, 2.87)	0.59
Model 2	1	0.97 (0.39, 2.39)	1.50 (0.56, 4.06)	0.42
MMP-9
Median (range), pg/mL	9730 (3653, 11838)	14257 (11885, 16952)	21908 (16960, 79902)
n	99	100	100
n AAA	12	24	36
Odds Ratio (95% CI)
Model 1	1	2.24 (0.95, 5.27)	6.50 (2.73, 15.50)	<0.001
Model 2	1	2.93 (1.06, 8.14)	7.44 (2.62, 21.15)	<0.001
IL-6
Median (range), pg/mL	1.15 (0.15, 1.54)	1.94 (1.55, 2.46)	3.28 (2.49, 10.50)
n	97	98	98
n AAA	20	20	31
Odds Ratio (95% CI)
Model 1	1	0.67 (0.28, 1.64)	1.15 (0.50, 2.62)	0.75
Model 2	1	0.63 (0.21, 1.90)	0.87 (0.32, 2.35)	0.79
PIIINP
Median (range), pg/mL	7463 (3838, 8988)	10717 (9015, 12679)	15277 (12698, 29416)
n	99	100	99
n AAA	16	29	27
Odds Ratio (95% CI)
Model 1	1	2.23 (0.97, 5.13)	1.90 (0.86, 4.20)	0.11
Model 2	1	3.17 (1.26, 7.94)	1.93 (0.72, 5.15)	0.19
Osteopontin
Median (range), ng/mL	4.55 (0.70, 5.50)	6.70 (5.60, 9.30)	19.65 (9.50, 79.80)
n	94	98	98
n AAA	23	18	27
Odds Ratio (95% CI)
Model 1	1	0.80 (0.32, 1.98)	1.49 (0.72, 3.12)	0.29
Model 2	1	0.57 (0.17, 1.85)	1.21 (0.55, 2.68)	0.64

Model 1: Adjusted for age, race and sex;

Model 2: Model 1 further adjusted for height, total cholesterol, triglycerides and smoking pack-years; p for trend from the analysis modeling tertile as an ordinal variable;

MMP=matrix metalloproteinase; CI=confidence interval; IL-6=interleukin-6; PIIINP=N-terminal propeptide of Type III procollagen