Table 3.

CYP2C copy number variant (CNV) allele and carrier frequencies.

	CYP2C18			CYP2C19			CYP2C9			CYP2C8			Any CYP2C gene
Cohort	Carriers/ Cohort	Allele Frequency (%)	Carrier Frequency (%)	Carriers/ Cohort	Allele Frequency (%)	Carrier Frequency (%)	Carriers/ Cohort	Allele Frequency (%)	Carrier Frequency (%)	Carriers/ Cohort	Allele Frequency (%)	Carrier Frequency (%)	Carriers/ Cohort	Allele Frequency (%)	Carrier Frequency (%)
Deletion
ISMMS/Sema4	7/11096	0.032	0.063	7/11096	0.032	0.063	0/11096	-	-	0/11096	-	-	7/11096	0.032	0.063
CMH	0/9760	-	-	3/9760	0.015	0.031	0/9760	-	-	0/9760	-	-	3/9760	0.015	0.031
DGV	38/41392	0.046	0.092	31/41392	0.037	0.075	4/41392	0.005	0.010	3/41392	0.004	0.007	50/41392	0.060	0.121
ClinGen	7/37447	0.009	0.019	5/37447	0.007	0.013	1/37447	0.001	0.003	1/37447	0.001	0.003	8/37447	0.011	0.021
Total:	52/99695	0.026	0.052	46/99695	0.023	0.046	5/99695	0.003	0.005	4/99695	0.002	0.004	68/99695	0.034	0.068
Duplication
ISMMS/Sema4	2/11096	0.009	0.018	2/11096	0.009	0.018	2/11096	0.009	0.018	2/11096	0.009	0.018	2/11096	0.009	0.018
CMH	0/9760	-	-	3/9760	0.015	0.031	3/9760	0.015	0.031	0/9760	-	-	3/9760	0.015	0.031
DGV	1/41392	0.001	0.002	3/41392	0.004	0.007	4/41392	0.005	0.010	4/41392	0.005	0.010	9/41392	0.016	0.022
ClinGen	2/37447	0.003	0.005	3/37447	0.004	0.003	4/37447	0.005	0.011	4/37447	0.005	0.011	5/37447	0.007	0.013
Total:	5/99695	0.002	0.005	10/99695	0.005	0.010	12/99695	0.006	0.012	10/99695	0.005	0.010	18/99695	0.009	0.018
Deletion/Duplication
ISMMS/Sema4	9/11096	0.041	0.081	9/11096	0.041	0.081	2/11096	0.009	0.018	2/11096	0.009	0.018	9/11096	0.041	0.081
CMH	0/9760	-	-	6/9760	0.031	0.061	3/9760	0.015	0.031	0/9760	-	-	6/9760	0.031	0.061
DGV	39/41392	0.047	0.094	34/41392	0.041	0.082	8/41392	0.010	0.019	7/41392	0.008	0.017	59/41392	0.076	0.143
ClinGen	9/37447	0.012	0.024	8/37447	0.011	0.021	5/37447	0.007	0.013	5/37447	0.007	0.013	13/37447	0.016	0.033
Total:	57/99695	0.029	0.057	57/99695	0.029	0.057	18/99695	0.009	0.018	14/99695	0.007	0.014	87/99695	0.044	0.087