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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Hum Mutat. 2019 Aug 17;40(11):2044–2056. doi: 10.1002/humu.23848

Figure 4.

Figure 4

Next-Generation sequencing of simple repeats from a subset of variant cell lines. Indels in simple repeat sequences were measured from genomic DNA by next-generation sequencing (NGS) for the p.H639R, p.S516I and p.S723F VUS lines as well as two abrogated (p.C199R and p.C697R) and two proficient controls (p.N127S and p.G322D) along with the WT and MSH2 knockout (KO) controls. Values indicate the number of indels in simple repeat sequences per megabase (Mb). The dashed gray line represents the threshold value for MSI-H (0.395 indels in simple repeats/Mb) as determined by NGS analysis of human tumors (Ni Huang et al., 2015).