Table 3.

The Effect of Dietary Supplements in Strata According to the Number of CFH or ARMS2 Risk Alleles

		Late Age-Related Macular Degeneration			Neovascular Age-Related Macular Degeneration			Any Geographic Atrophy
Supplements	CFH Risk Alleles	Hazard Ratio	95% Confidence Interval	P Value	Hazard Ratio	95% Confidence Interval	P Value	Hazard Ratio	95% Confidence Interval	P Value
Lutein and zeaxanthin	0	0.811	0.572–1.148	0.237	0.796	0.531–1.191	0.267	0.866	0.555–1.349	0.524
	1	0.985	0.820–1.183	0.872	0.981	0.792–1.215	0.862	0.967	0.767–1.218	0.774
	2	1.197	0.927–1.546	0.168	1.210	0.893–1.640	0.219	1.080	0.790–1.475	0.630
Omega-3 fatty acids	0	0.932	0.658–1.320	0.690	0.798	0.533–1.194	0.272	1.006	0.645–1.569	0.979
	1	1.068	0.889–1.284	0.481	0.963	0.777–1.193	0.729	1.111	0.881–1.401	0.375
	2	1.225	0.948–1.582	0.120	1.162	0.857–1.577	0.333	1.227	0.897–1.676	0.200
Low vs. high zinc	0	1.327	0.891–1.977	0.163	1.281	0.806–2.037	0.294	1.323	0.793–2.206	0.284
	1	1.101	0.892–1.359	0.369	1.179	0.922–1.509	0.189	0.993	0.759–1.299	0.958
	2	0.914	0.680–1.228	0.549	1.085	0.760–1.550	0.652	0.745	0.516–1.076	0.117
β-carotene	0	1.547	1.014–2.360	0.043	1.536	0.938–2.516	0.088	1.124	0.652–1.938	0.675
	1	1.312	1.051–1.638	0.016	1.260	0.971–1.635	0.083	1.103	0.831–1.464	0.496
	2	1.113	0.817–1.516	0.498	1.033	0.709–1.505	0.867	1.083	0.740–1.586	0.681
Lutein vs. β-carotene	0	0.632	0.362–1.103	0.106	0.632	0.329–1.213	0.168	0.862	0.420–1.768	0.685
	1	0.738	0.549–0.991	0.044	0.802	0.568–1.132	0.209	0.867	0.594–1.264	0.457
	2	0.862	0.561–1.324	0.497	1.017	0.610–1.693	0.950	0.872	0.511–1.489	0.615
	ARMS2 Risk Alleles
Lutein and zeaxanthin	0	1.152	0.883–1.504	0.297	0.978	0.709–1.348	0.890	1.141	0.822–1.583	0.431
	1	1.021	0.854–1.220	0.822	1.043	0.848–1.284	0.689	0.963	0.771–1.203	0.739
	2	0.904	0.652–1.254	0.546	1.114	0.765–1.621	0.574	0.813	0.537–1.229	0.326
Omega-3 fatty acids	0	1.085	0.830–1.417	0.552	1.060	0.768–1.462	0.725	1.032	0.743–1.434	0.851
	1	1.113	0.931–1.330	0.241	1.001	0.813–1.233	0.991	1.165	0.932–1.456	0.180
	2	1.141	0.823–1.582	0.428	0.946	0.650–1.377	0.772	1.314	0.870–1.986	0.194
Low vs. high zinc	0	1.217	0.891–1.662	0.218	1.109	0.764–1.611	0.586	1.248	0.843–1.847	0.269
	1	1.054	0.860–1.292	0.613	1.202	0.946–1.529	0.133	0.877	0.677–1.136	0.320
	2	0.913	0.630–1.323	0.630	1.303	0.843–2.015	0.234	0.616	0.382–0.994	0.047
β-carotene	0	1.046	0.752–1.456	0.789	0.901	0.607–1.339	0.607	1.185	0.783–1.792	0.422
	1	1.306	1.055–1.616	0.014	1.263	0.979–1.628	0.073	1.089	0.833–1.425	0.532
	2	1.629	1.104–2.404	0.014	1.769	1.114–2.807	0.016	1.002	0.612–1.640	0.994
Lutein vs. β-carotene	0	0.992	0.638–1.543	0.971	0.914	0.536–1.558	0.74	0.987	0.572–1.704	0.962
	1	0.737	0.552–0.983	0.038	0.833	0.595–1.166	0.287	0.845	0.586–1.219	0.368
	2	0.547	0.328–0.913	0.021	0.760	0.424–1.361	0.356	0.724	0.375–1.399	0.337