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. 2019 Oct 14;12:8411–8420. doi: 10.2147/OTT.S222426

Table 2.

Association Of EAAT1, DHFR, And Fetuin-A Expression With Clinicopathological Characteristics Of CS

Characteristic N EAAT1 Positive N (%) χ2 p DHFR Positive N (%) χ2 p Fetuin-A Positive N (%) χ2 p
Age, years
 <45 34 20 (58.8) 0.948 0.330 20 (58.8) 3.040 0.081 20 (58.8) 1.841 0.175
 ≥45 46 22 (47.8) 18 (39.1) 20 (43.5)
Sex
 Male 43 22 (51.2) 0.067 0.796 21 (48.8) 0.067 0.796 23 (53.5) 0.453 0.501
 Female 37 20 (54.1) 17 (45.9) 17 (45.9)
Differentiation
 Well 58 24 (41.4) 10.484 0.005 21 (36.2) 10.841 0.004 21 (36.2) 16.347 <0.001
 Moderate 12 10 (83.3) 9 (75.0) 11 (91.7)
 Poor 10 8 (80.0) 8 (80.0) 8 (80.0)
Tumor size
 <5 cm 24 10 (41.7) 1.614 0.204 10 (41.7) 0.468 0.494 11 (45.8) 0.238 0.626
 ≥5 cm 56 32 (57.1) 28 (50.0) 29 (51.8)
AJCC stage
 I 29 10 (34.5) 11.987 0.007 7 (24.1) 24.108 <0.001 5 (17.2) 24.812 <0.001
 II 32 16 (50.0) 13 (40.6) 18 (56.3)
 III 8 6 (75.0) 8 (100) 7 (87.5)
 IV 11 10 (90.9) 10 (90.9) 10 (90.9)
Enneking stage
 I 55 22 (40.0) 11.696 0.003 17 (30.9) 19.667 <0.001 17 (30.9) 25.685 <0.001
 II 15 11 (73.3) 12 (80.0) 14 (93.3)
 III 10 9 (90.0) 9 (90.0) 9 (90.0)
Metastasis
 No 69 33 (47.8) 4.396 0.036 28 (40.6) 9.637 0.002 30 (43.5) 8.538 0.003
 Yes 11 9 (81.8) 10 (90.9) 10 (90.9)
Invasion
 No 13 3 (23.1) 5.389 0.020 5 (38.5) 0.509 0.476 4 (30.8) 2.296 0.130
 Yes 67 39 (58.2) 33 (49.3) 36 (53.7)

Abbreviations: CS, chondrosarcoma; EAAT1, excitatory amino acid transporter 1; DHFR, Dihydrofolate reductase; N, number; AJCC, American Joint Committee on Cancer.