Table 1.
Evidence about the effectiveness of adherence-enhancing interventions
| Intervention subclass | OP studies | Other conditions* | Conclusion |
|---|---|---|---|
| Education and support | |||
| Patient education program | 4 | 4 | Mixed evidence of effectiveness |
| Patient counselling | 1 | 10 | Strong evidence of effectiveness |
| Patient education combined with counselling | 11 | 15 | Strong evidence of effectiveness |
| Provision of educational material | 2 | 5 | No evidence of effectiveness |
| Monitoring supervision | |||
| Non-adherence monitoring | 1 | 2 | Limited evidence of effectiveness |
| Adherence monitoring combined with counselling | 5 | 10 | Strong evidence of effectiveness |
| Drug regimen combined with counselling | 1 | 1 | Limited evidence of effectiveness |
| Reminders to take the medication | 1 | 7 | Strong evidence of effectiveness |
| Monitoring biomarkers | 3 | N/a | No evidence of effectiveness |
| Dose regimen adjustment and simplification | |||
| Dose simplification including flexible dosing regimen | 4 | 8 | Strong evidence of effectiveness |
| Individual medication program | 1 | 1 | Limited evidence of effectiveness |
| Costs covered | N/a | 1 | Limited evidence of effectiveness |
| Other subclasses | |||
| Combination of interventions mentioned above | 3 | 2 | Mixed evidence of effectiveness |
| Other interventions | 4 | 9 | Low evidence of effectiveness |
N/a not applicable
*Restricted to depression, cardiovascular diseases and hypercholesterolaemia