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Mean percentage change from baseline in bone turnover markers a serum-OC, b serum-P1NP, c urine-NTX, and d serum-CTX Bars indicate 95% confidence intervals. A comparison was performed using the Wilcoxon rank-sum test. Asterisk indicates (*) p < 0.05 versus 56.5-μg once-weekly; Two asterisks (**) p < 0.01 versus 56.5-μg once-weekly. Open circles, 28.2-μg twice-weekly; closed circles, 56.5-μg once-weekly
