TABLE 1.
Antimicrobial activity of minocycline tested against the main organisms and organism groups
| Organism/organism group (no. of isolates) | No. and cumulative % of isolates inhibited at MIC (μg/ml) of: |
MIC50 | MIC90 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4a | 8 | >b | |||
| A. baumannii-A. calcoaceticus complex (1,081) | 136 | 250 | 170 | 82 | 105 | 119 | 64 | 66 | 89 | 0.25 | 8 |
| 12.6 | 35.7 | 51.4 | 59.0 | 68.7 | 79.7 | 85.7 | 91.8 | 100.0 | |||
| MDR A. baumannii-A. calcoaceticus complex (539) | 4 | 21 | 35 | 53 | 98 | 112 | 61 | 66 | 89 | 2 | >8 |
| 0.7 | 4.6 | 11.1 | 21.0 | 39.1 | 59.9 | 71.2 | 83.5 | 100.0 | |||
| XDR A. baumannii-A. calcoaceticus complex (401) | 1 | 5 | 12 | 35 | 77 | 89 | 51 | 55 | 76 | 2 | >8 |
| 0.2 | 1.5 | 4.5 | 13.2 | 32.4 | 54.6 | 67.3 | 81.0 | 100.0 | |||
| S. maltophilia (1,289) | 3 | 72 | 296 | 480 | 265 | 126 | 41 | 3 | 3 | 0.5 | 2 |
| 0.2 | 5.8 | 28.8 | 66.0 | 86.6 | 96.4 | 99.5 | 99.8 | 100.0 | |||
| S. maltophilia (trimethoprim-sulfamethoxazole resistant, 69) | 0 | 1 | 7 | 15 | 20 | 15 | 6 | 3 | 2 | 1 | 4 |
| 0.0 | 1.4 | 11.6 | 33.3 | 62.3 | 84.1 | 92.8 | 97.1 | 100.0 | |||
| B. cepacia complex (101) | 1 | 0 | 1 | 4 | 30 | 43 | 10 | 7 | 5 | 2 | 8 |
| 1.0 | 1.0 | 2.0 | 5.9 | 35.6 | 78.2 | 88.1 | 95.0 | 100.0 | |||
a
CLSI M100 (29) susceptible breakpoint indicated by shaded column.
b
Greater than the highest concentration tested.