TABLE 2.
Activity of minocycline and comparators when tested against Acinetobacter baumannii-Acinetobacter calcoaceticus species complex, Stenotrophomonas maltophilia, and Burkholderia cepacia complex isolates from the United States (2014 to 2018)
| Organism/organism group (no. of isolates) and antimicrobial agent | MIC50 (μg/ml) | MIC90 (μg/ml) | Range (μg/ml) | CLSIa |
||
|---|---|---|---|---|---|---|
| %S | %I | %R | ||||
| A. baumannii-A. calcoaceticus complex (1,081) | ||||||
| Amikacin | 4 | >32 | ≤0.25–>32 | 79.2 | 2.6 | 18.2 |
| Ampicillin-sulbactam | 4 | >32 | 0.5–32 | 62.4 | 12.9 | 24.7 |
| Cefepime | 8 | >16 | ≤0.5–>16 | 50.8 | 11.5 | 37.7 |
| Ceftazidime | 8 | >32 | 0.5–>32 | 56.0 | 6.2 | 37.8 |
| Colistin | ≤0.5 | 2 | ≤0.5–>8 | 92.4 | 7.6 | |
| Gentamicin | ≤1 | >8 | ≤1–>8 | 64.0 | 5.1 | 30.9 |
| Imipenem | 0.25 | >8 | ≤0.12–>8 | 61.5 | 3.2 | 35.2 |
| Levofloxacin | 0.5 | >4 | ≤0.12–>4 | 55.2 | 1.9 | 42.9 |
| Meropenem | 1 | >32 | 0.06–>32 | 58.8 | 1.9 | 39.4 |
| Minocycline | 0.25 | 8 | ≤0.06–>8 | 85.7 | 6.1 | 8.2 |
| Piperacillin-tazobactam | 16 | >64 | ≤0.5–>64 | 50.2 | 7.6 | 42.1 |
| Tetracyclineb | 4 | >8 | ≤0.5–>8 | 51.8 | 6.1 | 42.1 |
| Trimethoprim-sulfamethoxazole | ≤0.5 | >4 | ≤0.5–>4 | 59.6 | 40.4 | |
| MDR A. baumannii-A. calcoaceticus complex (539)c | ||||||
| Amikacin | 8 | >32 | 0.5–>32 | 58.7 | 5.0 | 36.3 |
| Ampicillin-sulbactam | 16 | >32 | 1–>32 | 25.8 | 24.9 | 49.4 |
| Cefepime | >16 | >16 | 2–>16 | 7.8 | 18.4 | 73.8 |
| Ceftazidime | >32 | >32 | 2–>32 | 16.5 | 9.8 | 73.7 |
| Colistin | ≤0.5 | 4 | ≤0.5–>8 | 87.9 | 12.1 | |
| Gentamicin | >8 | >8 | ≤1–>8 | 30.1 | 9.3 | 60.7 |
| Imipenem | >8 | >8 | ≤0.12–>8 | 22.8 | 6.5 | 70.7 |
| Levofloxacin | >4 | >4 | ≤0.12–>4 | 11.3 | 3.3 | 85.3 |
| Meropenem | 32 | >32 | 0.12–>32 | 18.0 | 3.2 | 78.8 |
| Minocycline | 2 | >8 | ≤0.06–>8 | 71.2 | 12.2 | 16.5 |
| Piperacillin-tazobactam | >64 | >64 | ≤0.5–>64 | 7.1 | 12.8 | 80.1 |
| Tetracyclineb | >8 | >8 | ≤0.25–>8 | 10.2 | 8.2 | 81.6 |
| Trimethoprim-sulfamethoxazole | >4 | >4 | ≤0.5–>4 | 25.0 | 75.0 | |
| XDR A. baumannii-A. calcoaceticus (401)c | ||||||
| Amikacin | 32 | >32 | 0.5–>32 | 48.9 | 6.0 | 45.1 |
| Ampicillin-sulbactam | 32 | >32 | 2–>32 | 11.2 | 28.7 | 60.1 |
| Cefepime | >16 | >16 | 4–>16 | 2.5 | 15.2 | 82.3 |
| Ceftazidime | >32 | >32 | 2–>32 | 11.0 | 8.0 | 81.0 |
| Colistin | ≤0.5 | 4 | ≤0.5–>8 | 86.5 | 13.5 | |
| Gentamicin | >8 | >8 | ≤1–>8 | 18.0 | 9.5 | 72.6 |
| Imipenem | >8 | >8 | 0.25– >8 | 6.7 | 5.2 | 88.0 |
| Levofloxacin | >4 | >4 | 0.5–>4 | 1.2 | 3.0 | 95.8 |
| Meropenem | >32 | >32 | 1–>32 | 2.5 | 3.5 | 94.0 |
| Minocycline | 2 | >8 | 0.06–>8 | 67.3 | 13.7 | 19.0 |
| Piperacillin-tazobactam | >64 | >64 | 8–>64 | 0.2 | 6.2 | 93.5 |
| Tetracyclineb | >8 | >8 | 1–>8 | 3.4 | 6.2 | 90.5 |
| Trimethoprim-sulfamethoxazole | >4 | >4 | ≤0.5–>4 | 14.2 | 85.8 | |
| S. maltophilia (1,289) | ||||||
| Amikacin | >32 | >32 | 1–>32 | |||
| Ampicillin-sulbactam | >32 | >32 | 2>32 | |||
| Cefepime | >16 | >16 | ≤0.5–>16 | |||
| Ceftazidime | 32 | >32 | 0.5–>32 | 26.8 | 9.9 | 63.3 |
| Colistin | 4 | >8 | ≤0.5–>8 | |||
| Gentamicin | >8 | >8 | ≤1–>8 | |||
| Imipenem | >8 | >8 | 0.5–>8 | |||
| Levofloxacin | 1 | >4 | ≤0.12–>4 | 75.8 | 9.7 | 14.5 |
| Meropenem | >32 | >32 | 0.03–>32 | |||
| Minocycline | 0.5 | 2 | ≤0.06–>8 | 99.5 | 0.2 | 0.2 |
| Piperacillin-tazobactam | >64 | >64 | 2–>64 | |||
| Tetracyclineb | >8 | >8 | 0.5–>8 | |||
| Trimethoprim-sulfamethoxazole | ≤0.5 | 1 | ≤0.5–>4 | 94.6 | 5.4 | |
| Trimethoprim-sulfamethoxazole-resistant S. maltophilia (69) | ||||||
| Ceftazidime | >32 | >32 | 1–>32 | 20.3 | 4.3 | 75.4 |
| Levofloxacin | >4 | >4 | 0.5–>4 | 21.7 | 15.9 | 62.3 |
| Minocycline | 1 | 4 | 0.12–>8 | 92.8 | 4.3 | 2.9 |
| B. cepacia complex (101) | ||||||
| Amikacin | >32 | >32 | ≤0.25–>32 | |||
| Ampicillin-sulbactam | >32 | >32 | 1–>32 | |||
| Cefepime | 16 | >16 | ≤0.5–>16 | |||
| Ceftazidime | 2 | 8 | 0.5–>32 | 91.0 | 4.0 | 5.0 |
| Colistin | >8 | >8 | ≤0.5–8 | |||
| Gentamicin | >8 | >8 | ≤0.5–>8 | |||
| Imipenem | 4 | >8 | ≤0.12–>8 | |||
| Levofloxacin | 2 | >4 | ≤0.12–>4 | 71.3 | 9.9 | 18.8 |
| Meropenem | 2 | 8 | 0.06–>32 | 89.1 | 5.0 | 5.9 |
| Minocycline | 2 | 8 | ≤0.06–>8 | 88.1 | 6.9 | 5.0 |
| Piperacillin-tazobactam | 4 | 64 | ≤0.5–>64 | |||
| Tetracyclineb | >8 | >8 | 2–>8 | |||
| Trimethoprim-sulfamethoxazole | ≤0.5 | 2 | ≤0.5–>4 | 93.1 | 6.9 | |