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Effect of each dosage regimen on the counts of bacteria able to grow on agar plates containing 6 or 15 mg/liter of meropenem or 3 or 7.5 mg/liter of tobramycin. The results are represented as the average ± SE. To differentiate less-susceptible subpopulations from the predominant population, the antibiotic concentrations in agar were based upon Etest MICs, which were 1.5 mg/liter for meropenem and 0.75 mg/liter for tobramycin (9).
